Tuning the properties of surgical polymeric materials for improved soft-tissue wound closure and healing

被引:7
|
作者
Chen, Yunhua [1 ,2 ,3 ,4 ]
Chai, Muyuan [1 ]
Xuan, Chengkai [1 ]
Lin, Jiayi [2 ]
Yang, Huishang [3 ]
Li, Chunhui [2 ]
Xie, Manshan [2 ]
Ostrovidov, Serge [5 ]
Shi, Xuetao [1 ,2 ,3 ,4 ]
Mao, Chuanbin [6 ]
机构
[1] South China Univ Technol, Sch Mat Sci & Engn, Guangzhou 510640, Peoples R China
[2] South China Univ Technol, Natl Engn Res Ctr Tissue Restorat & Reconstruct, Guangzhou 510006, Peoples R China
[3] South China Univ Technol, Key Lab Biomed Engn Guangdong Prov, Guangzhou 510006, Peoples R China
[4] South China Univ Technol, Key Lab Biomed Mat & Engn, Minist Educ, Guangzhou 510006, Peoples R China
[5] Univ Calif Los Angeles, Dept Radiol Sci, Los Angeles, CA 90095 USA
[6] Chinese Univ Hong Kong, Dept Biomed Engn, Shatin, Hong Kong, Peoples R China
基金
中国国家自然科学基金;
关键词
Surgical materials; Wound healing; Biomaterials; Wound closures; RESPONSIVE INJECTABLE HYDROGELS; POLY(LACTIC ACID) NANOSHEETS; STEM-CELL DIFFERENTIATION; ANTIBACTERIAL ACTIVITY; HYALURONIC-ACID; ADHESIVE; SUTURES; DRUG; EFFICACY; DELIVERY;
D O I
10.1016/j.pmatsci.2024.101249
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Effective wound management is important, as millions of people suffer traumatic injuries and surgical operations annually. Proper wound closure is essential for the structural and functional restoration of damaged tissues. In addition to conventional sutures, various advanced surgical materials with multiple functions have been developed for more reliable and improved wound healing performance in the past few years. Here, polymeric surgical materials for soft tissue wound closure are comprehensively reviewed, including both commercially available materials and newly developed materials. These materials, based on natural, synthetic or composite polymers, are classified and discussed as invasive and non-invasive surgical materials. Their properties (antibacterial, hemostatic, stimuli-responsive, drug delivery, or a combination thereof) are critically analysed in the context of improving wound healing. Moreover, how to tune these properties (e.g., chemical grafting of antibacterial moieties, nano-enabled regulation of hemostasis, dual stimuli-responsive design, etc.) are clearly discussed. Finally, challenges in the field and potential solutions to tackle them are also proposed. This review should inspire more research efforts to develop the next generation of promising surgical polymeric materials for clinical applications.
引用
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页数:36
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