Heterologous Booster Immunization Based on Inactivated SARS-CoV-2 Vaccine Enhances Humoral Immunity and Promotes BCR Repertoire Development

被引：2

作者：

Li, Xinghang ^{[1
]}

Zeng, Fengyuan ^{[1
]}

Yue, Rong ^{[1
]}

Ma, Danjing ^{[1
]}

Meng, Ziyan ^{[1
]}

Li, Qi ^{[1
]}

Zhang, Zhenxiao ^{[1
]}

Zhang, Haobo ^{[1
]}

Liao, Yuansheng ^{[1
]}

Liao, Yun ^{[1
]}

Jiang, Guorun ^{[1
]}

Zhao, Heng ^{[1
]}

Yu, Li ^{[1
]}

Li, Dandan ^{[1
]}

Zhang, Ying ^{[1
]}

Liu, Longding ^{[1
]}

Li, Qihan ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biol, Yunnan Key Lab Vaccine Res & Dev Severe Infect Di, Kunming 650118, Peoples R China

来源：

VACCINES | 2024年 / 12卷 / 02期

基金：

中国国家自然科学基金;

关键词：

SARS-CoV-2; vaccine; sequential immunization; B-cell receptor; humoral immunity; B-CELL RECEPTOR; COVID-19; MECHANISMS; CLONING;

D O I：

10.3390/vaccines12020120

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have indicated that sequentially administering SARS-CoV-2 vaccines can result in increased antibody and cellular immune responses. In this study, we compared homologous and heterologous immunization strategies following two doses of inactivated vaccines in a mouse model. Our research demonstrates that heterologous sequential immunization resulted in more immune responses displayed in the lymph node germinal center, which induced a greater number of antibody-secreting cells (ASCs), resulting in enhanced humoral and cellular immune responses and increased cross-protection against five variant strains. In further single B-cell analysis, the above findings were supported by the presence of unique B-cell receptor (BCR) repertoires and diversity in CDR3 sequence profiles elicited by a heterologous booster immunization strategy.

引用

页数：18

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