Nickel-catalyzed Hydrodefluorination of ortho-Fluoro Aromatic Amides with 2-Propanol

被引：2
|
作者：
Morishige, Akoi [1 ]
Matsuura, Akihisa [1 ]
Chatani, Naoto [1 ,2 ]
机构：
[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita 5650871, Japan
[2] Osaka Univ, Res Ctr Environm Preservat, Suita, Osaka 5650871, Japan
来源：
CHEMISTRY LETTERS | 2023年 / 52卷 / 02期
关键词：
-F bond activation; Hydrodefluorination; Nickel; F BOND ACTIVATION;
D O I：
10.1246/cl.220485
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and direct hydrodefluorination (HDF) of ortho-fluoro aromatic amides using Ni(cod)2 as the catalyst, 2-propanol as a green reductant, and potassium tert-butoxide as a base is described. The reaction proceeds via the use of an amidate anion directing group. The reaction does not require any external ligands and the reaction proceeds at low temper-atures.
引用
收藏
页码：63 / 66
页数：4
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