Gold-Catalyzed Alkyne Multifunctionalization through an Oxidation-Oxyalkylation-Aryloxylation Sequence

被引：5
|
作者：
Xiong, Weichen [1 ]
Zhou, Su [1 ]
Zhang, Xinke [1 ]
Zhao, Jingyu [1 ]
Huang, Jingjing [1 ]
Hu, Wenhao [1 ]
Xu, Xinfang [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2023年
基金：
中国国家自然科学基金;
关键词：
TERMINAL ALKYNES; METHYL KETONES; ACTIVATION; ARYLATION;
D O I：
10.1021/acs.orglett.2c04115
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A gold-catalyzed oxidative three-component reaction of terminal alkynes with alcohols and quinone monoimines has been disclosed, affording alpha-ketoacetals in good to excellent yields. By using quinone monoimines as electrophiles for the interception of the in situ generated gold enolate intermediate, this one-pot process provides an unprecedented method for the polyfunctionalization of terminal alkynes through an oxidation-oxyalkylation- aryloxylation sequence, installing three oxygen atoms on the C-C triple bond.
引用
收藏
页码：405 / 409
页数：5
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