Lipid Metabolism as a Potential Target of Liver Cancer

被引:3
|
作者
Wu, Kangze [1 ]
Lin, Feizhuan [1 ]
机构
[1] Shaoxing Peoples Hosp, Dept Hepatobiliary Surg, Shaoxing, Peoples R China
关键词
cholesterol; fatty acid; hepatocellular carcinoma; lipid uptake; lipid catabolism; lipid synthesis; ATP CITRATE LYASE; ELEMENT-BINDING PROTEIN; FATTY-ACID-METABOLISM; COA SYNTHETASE 2; HEPATOCELLULAR-CARCINOMA; THERAPEUTIC TARGET; CELL-GROWTH; POOR-PROGNOSIS; BETA-OXIDATION; GASTRIC-CANCER;
D O I
10.2147/JHC.S450423
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with a profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving the prognosis of HCC remains a formidable challenge. It is noteworthy that lipid metabolism plays a pivotal role in the onset, development, and progression of tumor cells. Existing research indicates the potential application of targeting lipid metabolism in the treatment of HCC. This review aims to thoroughly explore the alterations in lipid metabolism in HCC, offering a detailed account of the potential advantages associated with innovative therapeutic strategies targeting lipid metabolism. Targeting lipid metabolism holds promise for potentially enhancing the prognosis of HCC.
引用
收藏
页码:327 / 346
页数:20
相关论文
共 50 条
  • [21] Arginine metabolism: a potential target in pancreatic cancer therapy
    Yang, Jin-Shou
    Wang, Cheng-Cheng
    Qiu, Jiang-Dong
    Ren, Bo
    You, Lei
    CHINESE MEDICAL JOURNAL, 2021, 134 (01) : 28 - 37
  • [22] Lipid metabolism in the liver
    Canbay, A.
    Bechmann, L.
    Gerken, G.
    ZEITSCHRIFT FUR GASTROENTEROLOGIE, 2007, 45 (01): : 35 - 41
  • [23] Liver lipid metabolism
    Nguyen, P.
    Leray, V.
    Diez, M.
    Serisier, S.
    Le Bloc'h, J.
    Siliart, B.
    Dumon, H.
    JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION, 2008, 92 (03) : 272 - 283
  • [24] Lipid Metabolism as a Therapeutic Target
    Smith, Terry K.
    Reynolds, Todd B.
    Denny, Paul W.
    BIOCHEMISTRY RESEARCH INTERNATIONAL, 2012, 2012
  • [25] The Complement System: A Potential Therapeutic Target in Liver Cancer
    Yuan, Meng
    Liu, Li
    Wang, Chenlin
    Zhang, Yan
    Zhang, Jiandong
    LIFE-BASEL, 2022, 12 (10):
  • [26] Aberrant Lipid Metabolism: An Emerging Diagnostic and Therapeutic Target in Ovarian Cancer
    Pyragius, Carmen E.
    Fuller, Maria
    Ricciardelli, Carmela
    Oehler, Martin K.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (04): : 7742 - 7756
  • [27] Cholesterol metabolism and lipid droplet vacuoles; a potential target for the therapy of aggressive lymphoma
    Yano, Hiromu
    Fujiwara, Yukio
    Komohara, Yoshihiro
    JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY, 2022, 62 (04) : 190 - 194
  • [28] NAMPT MEDIATED NAD METABOLISM, A POTENTIAL TARGET FOR POLYCYSTIC LIVER DISEASES
    Pant, Kishor
    Richard, Seth
    Gradilone, Sergio
    HEPATOLOGY, 2022, 76 : S1015 - S1016
  • [29] Lipid metabolism in pancreatic cancer: emerging roles and potential targets
    Yin, Xinpeng
    Xu, Ruiyuan
    Song, Jianlu
    Ruze, Rexiati
    Chen, Yuan
    Wang, Chengcheng
    Xu, Qiang
    CANCER COMMUNICATIONS, 2022, 42 (12) : 1234 - 1256
  • [30] Sphingolipid Metabolism and Signaling in Lung Cancer: A Potential Therapeutic Target
    Lin, Mengmeng
    Li, Yingying
    Wang, Shiyuan
    Cao, Bo
    Li, Chunyu
    Li, Guohui
    JOURNAL OF ONCOLOGY, 2022, 2022