Macrophage barrier in the tumor microenvironment and potential clinical applications

被引：19
|
作者：
Ji, Shuai [1 ]
Shi, Yuqing [2 ]
Yin, Bo [1 ]
机构：
[1] China Med Univ, Dept Urinary Surg, Shengjing Hosp, Shenyang 110022, Peoples R China
[2] Shenyang 10th Peoples Hosp, Dept Resp Med, Shenyang 110096, Peoples R China
来源：
CELL COMMUNICATION AND SIGNALING | 2024年 / 22卷 / 01期
关键词：
Macrophage; Tumor-associated macrophages (TAMs); Tumor microenvironment; Tumor immunology; PLASMACYTOID DENDRITIC CELLS; KILLER T-CELLS; HUMAN-MELANOMA; MYELOID CELLS; IN-VIVO; CANCER; NEUTROPHILS; DIFFERENTIATION; INDUCTION; RESPONSES;
D O I：
10.1186/s12964-023-01424-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The tumor microenvironment (TME) constitutes a complex microenvironment comprising a diverse array of immune cells and stromal components. Within this intricate context, tumor-associated macrophages (TAMs) exhibit notable spatial heterogeneity. This heterogeneity contributes to various facets of tumor behavior, including immune response modulation, angiogenesis, tissue remodeling, and metastatic potential. This review summarizes the spatial distribution of macrophages in both the physiological environment and the TME. Moreover, this paper explores the intricate interactions between TAMs and diverse immune cell populations (T cells, dendritic cells, neutrophils, natural killer cells, and other immune cells) within the TME. These bidirectional exchanges form a complex network of immune interactions that influence tumor immune surveillance and evasion strategies. Investigating TAM heterogeneity and its intricate interactions with different immune cell populations offers potential avenues for therapeutic interventions. Additionally, this paper discusses therapeutic strategies targeting macrophages, aiming to uncover novel approaches for immunotherapy.EjPgUqH7NocL1u9xj7AojmVideo Abstract
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页数：14
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