The link between obesity and aging - insights into cardiac energy metabolism

被引：5
|
作者：
Owesny, Patricia [1 ,2 ]
Grune, Tilman [1 ,2 ,3 ,4 ]
机构：
[1] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Toxicol, Nuthetal, Germany
[2] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany
[3] German Ctr Diabet Res DZD, Munchen Neuherberg, Germany
[4] German Inst Human Nutr Potsdam Rehbruecke DIfE, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2023年 / 216卷
关键词：
Mitochondria; Substrate utilization; Metabolic flexibility; Senescence; Heart failure; Diet-induced obesity; HIGH-FAT-DIET; PROTEIN-KINASE ACTIVITY; ACTIVATED RECEPTOR-ALPHA; MYOSIN HEAVY-CHAIN; HEART-FAILURE; OXIDATIVE STRESS; CONTRACTILE DYSFUNCTION; MITOCHONDRIAL-FUNCTION; SKELETAL-MUSCLE; GENE-EXPRESSION;
D O I：
10.1016/j.mad.2023.111870
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Obesity and aging are well-established risk factors for a range of diseases, including cardiovascular diseases and type 2 diabetes. Given the escalating prevalence of obesity, the aging population, and the subsequent increase in cardiovascular diseases, it is crucial to investigate the underlying mechanisms involved. Both aging and obesity have profound effects on the energy metabolism through various mechanisms, including metabolic inflexibility, altered substrate utilization for energy production, deregulated nutrient sensing, and mitochondrial dysfunction. In this review, we aim to present and discuss the hypothesis that obesity, due to its similarity in changes observed in the aging heart, may accelerate the process of cardiac aging and exacerbate the clinical outcomes of elderly individuals with obesity.
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页数：21
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