Mn(OAc)3-Mediated One-Pot Condensation-Oxidative Annulation of 2-Alkynylanilines and 1,3-Ketoesters: Synthesis of 2-Substituted Quinolines

被引：7
|
作者：
Punjajom, Kunlayanee [1 ]
Ruengsangtongkul, Sureeporn [2 ]
Tummatorn, Jumreang [1 ,2 ]
Paiboonsombat, Praneet [1 ]
Ruchirawat, Somsak [1 ,2 ]
Thongsornkleeb, Charnsak [1 ,2 ]
机构：
[1] Chulabhorn Grad Inst, Ctr Excellence Environm Hlth & Toxicol EHT, Program Chem Biol, Minist Educ, Bangkok 10210, Thailand
[2] Chulabhorn Res Inst, Lab Med Chem, Bangkok 10210, Thailand
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 11期
关键词：
GAMMA-LACTONES; CYCLIZATION; ACETATE; ALKYNES;
D O I：
10.1021/acs.joc.3c00027
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general protocol for oxidative annulation was developed for the preparation of 2-methyl-3,4-diacylquinolines directly from 2-alkynylanilines and 1,3-ketoesters. The reactions were mediated by Mn(OAc)3 in acetic acid at room temperature, which led to the desired quinoline products in one-pot in low to good overall yields on a wide range of substrates. The current method was convenient to conduct and proceeded under mild conditions in short reaction times.
引用
收藏
页码：6736 / 6749
页数：14
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