Structural characterization of water-soluble polysaccharides from Sophora flavescens Ait. and their anti-inflammatory activities based on NO release

被引：3
|
作者：
Li, Yi-Xuan [1 ,2 ]
Lu, Bo-Wen [1 ,2 ]
Jiang, Si-Liang [1 ,2 ]
Dong, Cai-Xia [2 ]
Du, Juan [1 ]
机构：
[1] Jiamusi Univ, Coll Pharm, Dept Pharmacognosy, Jiamusi 154007, Peoples R China
[2] Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin 300070, Peoples R China
来源：
JOURNAL OF CARBOHYDRATE CHEMISTRY | 2023年 / 41卷 / 7-9期
基金：
中国国家自然科学基金;
关键词：
Anti-inflammatory effect; polysaccharide; Sophora flavescens Ait; structural characterization; ESTERIFICATION; ANTIOXIDANT;
D O I：
10.1080/07328303.2023.2174551
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sophora flavescens Ait. is a medicinal herb traditionally used to treat inflammatory diseases. In this study, four polysaccharides, SFNP-1, SFNP-2, SFAP-1, and SFAP-2, were isolated from S. flavescens. Both SFNP-1 and SFNP-2 were (1 -> 4)-linked glucans. SFAP-1 and SFAP-2 were identified as pectin-type polysaccharides containing mainly a homo-galacturanan backbone (as shown). NO release inhibition test revealed that the major polysaccharides, SFAP-1 and SFAP-2, did not have a significant anti-inflammatory effect. This result suggests that the anti-inflammatory effect of S. flavescens may not depend on its polysaccharides.
引用
收藏
页码：405 / 423
页数：19
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