Rhodium(II)-Catalyzed N-H Insertions of Carbenes under Mechanochemical Conditions

被引：5
|
作者：
Biswas, Sourav [1 ]
Bolm, Carsten [1 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 07期
关键词：
DIAZOACETATES; BONDS; CATALYST; TOOL;
D O I：
10.1021/acs.orglett.4c00216
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Under mechanochemical conditions in a mixer mill, Rh-2(OAc)(4) catalyzes the reaction between aryldiazoesters and anilines to give alpha-amino esters. The process proceeds under mild conditions and is insensitive to air. It is solvent-free and scalable. A broad substrate scope, short reaction times, operational simplicity, and good functional group tolerance are additional salient features of this protocol.
引用
收藏
页码：1511 / 1516
页数：6
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