The placental syndromes gestational hypertension, preeclampsia and intrauterine growth restriction are associated with an increased cardiovascular risk to the mother later in life. In this review, we argue that a woman's pre-conception cardiovascular health drives both the development of placental syndromes and long-term cardiovascular risk but acknowl-edge that placental syndromes can also contribute to future cardiovascular risk independent of pre-conception health. We describe how preclinical studies in models of preeclampsia inform our understanding of the links with later cardiovascular disease, and how current pre-pregnancy studies may explain relative contributions of both pre-conception factors and the occurrence of placental syndromes to long-term cardiovascular disease.
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Imperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Canc, London, EnglandImperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
Tay, Jasmine
Masini, Giulia
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Imperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, EnglandImperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
Masini, Giulia
McEniery, Carmel M.
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Univ Cambridge, Div Expt Med & Immunotherapeut, Cambridge, EnglandImperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
McEniery, Carmel M.
Giussani, Dino A.
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Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, EnglandImperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
Giussani, Dino A.
Shaw, Caroline J.
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Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Canc, London, EnglandImperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
Shaw, Caroline J.
Wilkinson, Ian B.
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Univ Cambridge, Div Expt Med & Immunotherapeut, Cambridge, EnglandImperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
Wilkinson, Ian B.
Bennett, Phillip R.
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Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Canc, London, EnglandImperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
Bennett, Phillip R.
Lees, Christoph C.
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Imperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England
Imperial Coll London, Inst Reprod & Dev Biol, Dept Surg & Canc, London, England
Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, BelgiumImperial Coll Healthcare NHS Trust, Ctr Fetal Care, Queen Charlottes & Chelsea Hosp, London, England