Antidiabetic Effect of Actinodaphne angustifolia and Profiling of Bioactive Metabolites using UPLC-QToF/ESI-MS Method

被引：0
|
作者：
Shaekh, Md. F. [1 ]
Maznah, Wan W., I [1 ]
Fasihi, Mohd Fadhlizil M. A. [3 ,4 ]
Uddin, Shihab A. [5 ]
Kamrul, R. [2 ]
Nizam, Saiful T. [3 ]
Moyeenul, Akm H. [3 ,5 ]
机构：
[1] Univ Malaysia Pahang, Fac Chem & Proc Engn Technol, Kuantan 26300, Pahang, Malaysia
[2] Incepta Pharmaceut Ltd, Qual Assurance Dept, Zirabo Unit, Dhaka 1340, Bangladesh
[3] Univ Malaysia Pahang, Bio Aromat Res Ctr, Kuantan 26300, Pahang, Malaysia
[4] Univ Malaysia Pahang, Fac Ind Sci & Technol, Kuantan 26300, Pahang, Malaysia
[5] Univ Asia Pacific, Sch Med, Dept Pharm, 74-A Green Rd, Dhaka 1205, Bangladesh
来源：
MEDICINE AND HEALTH | 2023年 / 18卷 / 01期
关键词：
antidiabetic activity; Actinodaphne angustifolia; phytochemical; UPLC-QTOF/ESI-MS; OXIDATIVE STRESS; IN-VITRO; QUERCETIN; INFLAMMATION; ANTIOXIDANT; FLAVONOIDS; LOGANIN; CELL; MACROPHAGES; EXPRESSION;
D O I：
10.17576/MH.2023.1801.12
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetes mellitus is a chronic disorder that causes elevated blood glucose levels due to a lack of insulin, either completely or partially. We investigated the antidiabetic property of Actinodaphne angustifolia in a rat model and identified the bioactive phytochemicals by using the UPLC-QTOF/ESI-MS method. The rats' pancreatic structures, lipid profile and blood glucose were assessed after a one-week intervention. UPLC-QTOF/ESI-MS analysis was conducted to identify flavonoids and terpenoids in the leaf extract. Actinodaphne angustifolia extract markedly increased the high- density lipoprotein (HDL) (p<0.05) while reducing total cholesterol (TC), low-density lipoprotein (LDL) and blood glucose. Furthermore, the tissue architecture of pancreatic islets was also well recovered as compared to the control group. A total of 45 flavonoids and 109 terpenoid compounds were identified using UPLC- QTOF/ESI-MS-based analysis and additional studies should be undertaken to identify the potential antidiabetic agents.
引用
收藏
页码：117 / 135
页数：19
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