FeCl3-Catalyzed C(sp3)-H Heteroarylation Enabled by Photoinduced Ligand-to-Metal Charge Transfer

Herein, we report a strategy for pyrimidination of inert alkanes via synergistic visible light-driven redox reaction and FeCl3 catalysis. This transformation involves C-H activation by a chlorine radical generated during the iron-promoted ligand-to-metal charge transfer process, triggering subsequent C-H pyrimidination. The substrates and catalysts are inexpensive and readily available, while the reaction conditions and procedures are simple without the need for external oxidants. This work provides a practical approach for synthesizing pyrimidine derivatives with high structural diversity.