EPAC1 boosts thermogenic adipocyte formation

被引：2
|
作者：
Rosen, Evan D. [1 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA
来源：
NATURE CELL BIOLOGY | 2024年 / 26卷 / 01期
关键词：
D O I：
10.1038/s41556-023-01304-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
beta-adrenergic signalling induces thermogenesis in mature brown adipocytes through a well-known cAMP-protein kinase A (PKA) pathway and also promotes the growth and differentiation of new thermogenic adipocytes. A study now demonstrates that beta-adrenergic agonists drive this pathway through a PKA-independent mechanism involving cAMP-EPAC1.
引用
收藏
页码：39 / 40
页数：2
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