Cyclodextrin Based Host-Guest Inclusion Complex, an Approach to Enhancing the Physicochemical and Biopharmaceutical Application of Poorly Water-soluble Drugs

Host-guest inclusion complexes have been extensively studied for drug delivery applications. The host molecule, typically cyclodextrin, creates a cavity, in which the guest molecule, such as a drug, can be encapsulated. This encapsulation can protect the drug from degradation, improve its solubility and stability, and enhance its bioavailability. Moreover, host-guest inclusion complexes can facilitate targeted drug delivery by selectively releasing drugs at the site of action. Various techniques, such as covalent bonding, non-covalent interactions, and self-assembly have been used to form these complexes. Host-guest inclusion complexes have shown great potential for improving the efficacy and safety of drug delivery systems. This mini review summarizes the application and recent progress of the cyclodextrin-based host-guest inclusion complex, highlighting the enhanced physicochemical and biopharmaceutical application of pharmaceutical drugs via formulation of its inclusion complex.