Genetic alterations in prostate cancer as diagnostic and prognostic markers

被引：0

作者：

Saeidi, Hamidreza ^{[1
]}

Ismail, Patimah ^{[1
]}

Samudi Raju, Chandramathi ^{[2
]}

Khairul-Asri, Mohd Ghani ^{[3
]}

Bakrin, Ikmal Hisyam ^{[4
]}

机构：

[1] Univ Putra Malaysia, Dept Biomed Sci, Fac Med & Hlth Sci, Serdang, Malaysia

[2] Univ Malaya, Dept Med Microbiol, Fac Med, Kuala Lumpur, Malaysia

[3] Univ Putra Malaysia, Dept Urol, Fac Med & Hlth Sci, Seri Kembangan, Selangor, Malaysia

[4] Putra Malaysia Univ, Dept Pathol, Fac Med & Hlth Sci, Serdang, Malaysia

来源：

MALAYSIAN JOURNAL OF PATHOLOGY | 2023年 / 45卷 / 02期

关键词：

Prostate cancer; genetic alterations; diagnostic markers; prognostic markers; EARLY PSA RECURRENCE; GERMLINE MUTATIONS; SPOP MUTATIONS; PTEN LOSS; MEN; ABIRATERONE; OUTCOMES; FUSION; TP53; RISK;

D O I：

暂无

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Prostate cancer is the second-most frequently diagnosed cancer in men worldwide. Serum prostate-specific antigen is currently used for the early detection of prostate cancer. However, new biomarkers are needed to decrease over diagnosis and over treatment of prostate cancer due to limitations of prostate-specific antigen. Recently, molecular biomarkers have shown promising results for diagnosis and prognosis of prostate cancer. Molecular biomarkers have improved the sensitivity and specificity of prostate-specific antigen and studies are ongoing to identify molecular biomarkers as a replacement for prostate-specific antigen. This review aims to give an overview of emerging molecular biomarkers for diagnosis and prognosis of prostate cancer.

引用

页码：149 / 155

页数：7

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