IL-18 secreting chimeric antigen receptor T cells targeting glypican-3show superior persistence and antitumor immunity against hepatocellular carcinoma

被引：1
|
作者：
Jeong, Joseph H.
Chang, Young-Kyun
Kang, You-Yeon
Lee, Jeong-Yun
Lee, Sae-Rom
Lee, Yun-Kyung
Kim, Young-Ho
Kwon, Byoung S.
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 08期
关键词：
D O I：
10.1158/1538-7445.AM2023-LB090
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
LB090
引用
收藏
页数：2
相关论文
共 50 条
  • [41] Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells
    Du, Hongwei
    Hirabayashi, Koichi
    Ahn, Sarah
    Kren, Nancy Porterfield
    Montgomery, Stephanie Ann
    Wang, Xinhui
    Tiruthani, Karthik
    Mirlekar, Bhalchandra
    Michaud, Daniel
    Greene, Kevin
    Herrera, Silvia Gabriela
    Xu, Yang
    Sun, Chuang
    Chen, Yuhui
    Ma, Xingcong
    Ferrone, Cristina Rosa
    Pylayeva-Gupta, Yuliya
    Yeh, Jen Jen
    Liu, Rihe
    Savoldo, Barbara
    Ferrone, Soldano
    Dotti, Gianpietro
    CANCER CELL, 2019, 35 (02) : 221 - +
  • [42] Increased antitumor activities of glypican-3-specific chimeric antigen receptor-modified T cells by coexpression of a soluble PD1-CH3 fusion protein
    Pan, Zeyan
    Di, Shengmeng
    Shi, Bizhi
    Jiang, Hua
    Shi, Zhimin
    Liu, Ying
    Wang, Yi
    Luo, Hong
    Yu, Min
    Wu, Xiuqi
    Li, Zonghai
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2018, 67 (10) : 1621 - 1634
  • [43] NKT Cells Co-Expressing a GD2-Specific Chimeric Antigen Receptor and IL-15 Show Enhancedin Vivopersistence and Antitumor Activity Against Neuroblastoma
    Xu, Xin
    Huang, Wei
    Heczey, Andras
    Liu, Daofeng
    Guo, Linjie
    Wood, Micheal
    Jin, Jinglin
    Courtney, Amy
    Liu, Bin
    DiPiero, Erica
    Hicks, John
    Barragan, Gabriel
    Savoldo, Barbara
    Dotti, Gianpietro
    Metelitsa, Leonid
    MOLECULAR THERAPY, 2019, 27 (04) : 174 - 174
  • [44] Increased antitumor activities of glypican-3-specific chimeric antigen receptor-modified T cells by coexpression of a soluble PD1–CH3 fusion protein
    Zeyan Pan
    Shengmeng Di
    Bizhi Shi
    Hua Jiang
    Zhimin Shi
    Ying Liu
    Yi Wang
    Hong Luo
    Min Yu
    Xiuqi Wu
    Zonghai Li
    Cancer Immunology, Immunotherapy, 2018, 67 : 1621 - 1634
  • [45] Human T cells engineered with an HLA-A2-restricted murine T-cell receptor targeting glypican 3 effectively control human hepatocellular carcinoma in mice
    Vercher, Enric
    Covo-Vergara, Angela
    Conde, Enrique
    Hernandez-Rueda, Mercedes
    Elizalde, Edurne
    Mancheno, Uxua
    Glez-Vaz, Javier
    Tamayo-Uria, Ibon
    Garcia-Garcia, Maritza R.
    Ferrer-Roig, Marta
    Maranon-Lopez, Javier
    Reparaz, David
    Ruiz, Marta
    de Cerio, Ascension Lopez-Diaz
    Inoges, Susana
    Inarrairaegui, Mercedes
    Lasarte, Juan J.
    Sangro, Bruno
    Sarobe, Pablo
    Hervas-Stubbs, Sandra
    HEPATOLOGY, 2024,
  • [46] Enhanced cytotoxicity against cholangiocarcinoma by fifth-generation chimeric antigen receptor T cells targeting integrin αvβ6 and secreting anti-PD-L1 scFv
    Nattaporn Phanthaphol
    Chalermchai Somboonpatarakun
    Kwanpirom Suwanchiwasiri
    Pornpimon Yuti
    Jatuporn Sujjitjoon
    Punn Augsornworawat
    George S. Baillie
    Mutita Junking
    Pa-thai Yenchitsomanus
    Journal of Translational Medicine, 23 (1)
  • [47] Chimeric Antigen Receptor T Cells Targeting NKG2D-Ligands Show Robust Efficacy Against Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia
    Driouk, Lina
    Gicobi, Joanina K.
    Kamihara, Yusuke
    Rutherford, Kayleigh
    Dranoff, Glenn
    Ritz, Jerome
    Baumeister, Susanne H. C.
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [48] Chimeric Antigen Receptor T Cells Targeting NKG2D-Ligands Show Robust Efficacy Against Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia
    Driouk, Lina
    Gicobi, Joanina
    Kamihara, Yusuke
    Rutherford, Kayleigh
    Dranoff, Glenn
    Ritz, Jerome
    Baumeister, Susanne H. C.
    BLOOD, 2019, 134
  • [49] T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo
    Tang, Xiaojun
    Zhou, Yan
    Li, Wenjie
    Tang, Qi
    Chen, Renjie
    Zhu, Jin
    Feng, Zhenqing
    JOURNAL OF BIOMEDICAL RESEARCH, 2014, 28 (06): : 468 - 475
  • [50] T cells expressing a LMP1-specific chimeric antigen receptor mediate antitumor effects against LMP1-positive nasopharyngeal carcinoma cells in vitro and in vivo
    Xiaojun Tang
    Yan Zhou
    Wenjie Li
    Qi Tang
    Renjie Chen
    Jin Zhu
    Zhenqing Feng
    The Journal of Biomedical Research, 2014, 28 (06) : 468 - 475
12345