Anti-Inflammatory Phomalones from the Deep-Sea-Derived Fungus Trichobotrys effuse FS522

被引：2
|
作者：
Huang, Hui-Bin [1 ,2 ]
Chen, Yu-Chan [2 ]
Wen, Ting-Yue [1 ,2 ]
Li, Sai-Ni [2 ]
Liu, Zhao-Ming [2 ]
Zhang, Wei-Min [2 ]
Gao, Xiao-Xia [1 ,2 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Pharm, 280 Huandong Rd, Guangzhou 510006, Peoples R China
[2] Guangdong Inst Microbiol South China State Key Lab, Guangdong Prov Key Lab Microbial Culture Collect &, 100 Cent Xianlie Rd, Guangzhou 510070, Peoples R China
来源：
CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 12期
关键词：
anti-inflammatory; deep-sea-derived fungus; phomalones; spectroscopic analysis; Trichobotrys effuse;
D O I：
10.1002/cbdv.202301512
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four new phomalones A-D (<bold>1</bold>-<bold>4</bold>), together with five known analogues (<bold>5</bold>-<bold>9</bold>) were isolated from the deep-sea-derived fungus Trichobotrys effuse FS522. Their structures of the new compounds established by analysis of their NMR and HR-ESI-MS spectroscopic data, and the absolute configurations of <bold>2</bold> was determined by electronic circular dichroism (ECD) calculations. compounds <bold>4</bold>, <bold>6</bold> and <bold>8</bold> substantially inhibited the production of nitric oxide (NO) with IC50 values of 4.64, 13.90, and 34.07 mu M.
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页数：5
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