Diverging asymmetry of intrinsic functional organization in autism

被引:8
|
作者
Wan, Bin [1 ,2 ,3 ,4 ,5 ]
Hong, Seok-Jun [6 ]
Bethlehem, Richard A. I. [7 ]
Floris, Dorothea L. [8 ,9 ]
Bernhardt, Boris C. [10 ]
Valk, Sofie L. [1 ,5 ,11 ]
机构
[1] Max Planck Inst Human Cognit & Brain Sci, Otto Hahn Res Grp Cognit Neurogenet, Leipzig, Germany
[2] Int Max Planck Res Sch Neurosci Communicat Funct S, Leipzig, Germany
[3] Univ Leipzig, Univ Hosp Leipzig, Dept Cognit Neurol, Leipzig, Germany
[4] Univ Leipzig, Fac Med, Leipzig, Germany
[5] Inst Neurosci & Med INM 7 Brain & Behav, Res Ctr Julich, Julich, Germany
[6] Sungkyunkwan Univ, Inst Basic Sci, Ctr Neurosci Imaging Res, Dept Global Biomed Engn, Suwon, South Korea
[7] Univ Cambridge, Dept Psychol, Cambridge, England
[8] Univ Zurich, Dept Psychol, Zurich, Switzerland
[9] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Med Ctr, Dept Cognit Neurosci, Nijmegen, Netherlands
[10] McGill Univ, Montreal Neurol Inst & Hosp, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
[11] Heinrich Heine Univ Dusseldorf, Inst Syst Neurosci, Dusseldorf, Germany
基金
加拿大健康研究院;
关键词
SPECTRUM DISORDER; CORPUS-CALLOSUM; LANGUAGE LATERALIZATION; SEX-DIFFERENCES; CHILDREN; HERITABILITY; ADOLESCENTS; COMMUNICATION; CONNECTIVITY; PREVALENCE;
D O I
10.1038/s41380-023-02220-x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autism is a neurodevelopmental condition involving atypical sensory-perceptual functions together with language and socio-cognitive deficits. Previous work has reported subtle alterations in the asymmetry of brain structure and reduced laterality of functional activation in individuals with autism relative to non-autistic individuals (NAI). However, whether functional asymmetries show altered intrinsic systematic organization in autism remains unclear. Here, we examined inter- and intra-hemispheric asymmetry of intrinsic functional gradients capturing connectome organization along three axes, stretching between sensory-default, somatomotor-visual, and default-multiple demand networks, to study system-level hemispheric imbalances in autism. We observed decreased leftward functional asymmetry of language network organization in individuals with autism, relative to NAI. Whereas language network asymmetry varied across age groups in NAI, this was not the case in autism, suggesting atypical functional laterality in autism may result from altered developmental trajectories. Finally, we observed that intra- but not inter-hemispheric features were predictive of the severity of autistic traits. Our findings illustrate how regional and patterned functional lateralization is altered in autism at the system level. Such differences may be rooted in atypical developmental trajectories of functional organization asymmetry in autism.
引用
收藏
页码:4331 / 4341
页数:11
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