Pd-Catalyzed Dehydrative Synthesis of Allylic Amines in Water

被引：9

作者：

Yu, Jing ^{[1
]}

Yan, Xiaoyu ^{[1
]}

Liu, Feng ^{[1
]}

Zhou, Ying ^{[1
]}

Man, Wenxin ^{[1
]}

Ma, Xiantao ^{[1
]}

机构：

[1] Xinyang Normal Univ, Coll Chem & Chem Engn, Green Catalysis & Synth Key Lab Xinyang City, Xinyang 46400, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Allylic Amine; Allylic Alcohol; Water Media; Tsuji-Trost Reaction; Green Chemistry; TSUJI-TROST REACTION; C-N BONDS; DIRECT AMINATION; ORGANIC-REACTIONS; CROSS-COUPLINGS; ALCOHOLS; ALKYLATION; ACTIVATION; COMPLEXES; LIGANDS;

D O I：

10.1002/ajoc.202300071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild Pd-catalyzed Tsuji-Trost reaction of allylic alcohols with an amine nucleophile in water media was developed, leading to the green synthesis of the valuable allylic amines. This new method requires no chemical activators and sophisticated soluble ligands, and can be easily scaled up in gram scale and be readily extended to the gram scale synthesis of Naftifine, one of the best-selling antifungal drugs, showing the practical value of this new method.

引用

页数：4

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