Microwave-promoted multi-component and green synthesis of thiadiazolo[3,2-a]pyrimidines under solvent-free conditions

被引：0
|
作者：
Pouramiri, Behjat [1 ]
Rashidi, Mohsen [2 ]
机构：
[1] Qom Univ Technol, Dept Organ Chem, Qom 37195, Iran
[2] Shahid Bahonar Univ Kerman, Fac Sci, Dept Chem, Kerman 76169, Iran
来源：
JOURNAL OF CHEMICAL SCIENCES | 2023年 / 135卷 / 03期
关键词：
Multi-component reaction (MCRs); microwave irradiation; thiadiazolo[2,3-a]pyrimidines; green synthesis; IONIC LIQUIDS; ONE-POT; DERIVATIVES;
D O I：
10.1007/s12039-023-02217-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This research is aimed at synthesizing pyrimidine heterocycles that contain 1,3,4-thiadiazole ring moiety by microwave-assisted multi-component reactions. For this purpose, synthesizing of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was carried out in a single-step reaction using aromatic aldehydes, ethyl acetoacetate, and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1 respectively) in the presence of [Et3NH]+[HSO4]- ionic liquid, under solvent-free conditions.Graphical abstractThis research, synthesis of [1,3,4] thiadiazolo[3,2-a]pyrimidine-6-carboxylate derivatives was carried out in a single-step reaction using aromatic aldehydes, ethyl acetoacetate and different derivatives of 1,3,4-thiadiazoles (with molar ratio of 1:2:1, respectively) in the presence of [Et3NH]+[HSO4]- ionic liquid under solvent-free microwave irradiation.
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页数：10
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