Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy

被引:0
|
作者
Chen, Guan-Yu [1 ,2 ]
Kuo, Kung-Kai [3 ]
Chuang, Shih-Chang [3 ]
Tseng, Kuang-Yi [1 ,2 ]
Wang, Shen-Nien [3 ]
Chang, Wen-Tsan [3 ]
Cheng, Kuang-, I [1 ,2 ]
机构
[1] Kaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Coll Med, Dept Anesthesiol, Kaohsiung 807, Taiwan
[3] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung 807, Taiwan
来源
MEDICINA-LITHUANIA | 2024年 / 60卷 / 02期
关键词
laparoscopic cholecystectomy; patient control analgesia; post-operative pain; nalbuphine; PAIN; APPENDECTOMY;
D O I
10.3390/medicina60020195
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Objectives: Optimal opioid analgesia is an excellent analgesia that does not present unexpected adverse effects. Nalbuphine, acting on the opioid receptor as a partial mu antagonist and kappa agonist, is considered a suitable option for patients undergoing laparoscopic surgery. Therefore, we aim to investigate the appropriate dosage of nalbuphine for post-operative pain management in patients with laparoscopic cholecystectomy. Materials and Methods: Patients were randomly categorized into low, medium, and high nalbuphine groups. In each group, a patient control device for post-operative pain control was programed with a low (0.05 mg/kg), medium (0.10 mg/kg), or high (0.20 mg/kg) nalbuphine dose as a loading dose and each bolus dose with a lockout interval of 7 min and without background infusion. Primary and secondary outcomes included the post-operative pain scale and nalbuphine consumption, and episodes of post-operative opioid-related adverse events and satisfactory scores. Results: The low-dosage group presented a higher initial self-reported pain score in comparison to the other two groups for the two hours post-op (p = 0.039) but presented lower nalbuphine consumption than the other two groups for four hours post-op (p = 0.047). There was no significant difference in the analysis of the satisfactory score and adverse events. Conclusions: An appropriate administration of nalbuphine could be 0.1 to 0.2 mg/kg at the initial four hours; this formula could be modified to a lower dosage (0.05 mg/kg) in the post-operative management of laparoscopic cholecystectomy.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Effect of controlled hyperventilation on post-laparoscopic cholecystectomy shoulder pain: a prospective randomized controlled trial
    Li, Ji
    Zhao, Huatang
    Sheng, Chen
    Liu, Yingchao
    Zhan, Ruijing
    LANGENBECKS ARCHIVES OF SURGERY, 2025, 410 (01)
  • [42] COMPARISON OF ANALGESIC EFFECT OF INTRAMUSCULAR AND ORAL NALBUPHINE IN PATIENTS WITH POST-OPERATIVE PAIN
    BEAVER, WT
    FEISE, G
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 1978, 23 (01) : 108 - 109
  • [43] Effects of low dose dexmedetomidine infusion on haemodynamic stress response, sedation and post-operative analgesia requirement in patients undergoing laparoscopic cholecystectomy
    Manne, Gourishankar Reddy
    Upadhyay, Mahendra R.
    Swadia, V. N.
    INDIAN JOURNAL OF ANAESTHESIA, 2014, 58 (06) : 726 - 731
  • [44] The impact of varying post-operative dressing size on recovery from laparoscopic cholecystectomy
    Heinrich, M.
    Ogden, J.
    Patel, A. G.
    PSYCHOLOGY HEALTH & MEDICINE, 2014, 19 (02) : 222 - 234
  • [45] Etoricoxib pre-medication for post-operative pain after laparoscopic cholecystectomy
    Puura, A.
    Puolakka, P.
    Rorarius, M.
    Salmelin, R.
    Lindgren, L.
    ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2006, 50 (06) : 688 - 693
  • [46] Post-operative ascites of unknown origin after laparoscopic cholecystectomy: Case report
    Farzaneh, Babak Alavi
    Alipour, Mehdi
    Reisi-Vanani, Vahid
    ANNALS OF MEDICINE AND SURGERY, 2022, 76
  • [47] Prospective randomized controlled trial comparing standard analgesia with combined intra-operative cystic plate and port-site local anesthesia for post-operative pain management in elective laparoscopic cholecystectomy
    Mladjan Protic
    Radovan Veljkovic
    Anton J. Bilchik
    Ana Popovic
    Milana Kresoja
    Aviram Nissan
    Itzhak Avital
    Alexander Stojadinovic
    Surgical Endoscopy, 2017, 31 : 704 - 713
  • [48] The Effect of Post-Operative Handgrip Exercise on the Maturation of Arteriovenous Fistula: a Randomized Controlled Trial
    Manjunath, Pol Maruti
    Gurpremjit, Singh
    Devender, Singh
    Surabhi, Vyas
    Ramana, Arumugaswamy Prasanna
    Sreenivas, V
    Aggarwal, S. K.
    INDIAN JOURNAL OF SURGERY, 2021, 83 (04) : 920 - 925
  • [49] The Effect of Post-Operative Handgrip Exercise on the Maturation of Arteriovenous Fistula: a Randomized Controlled Trial
    Pol Maruti Manjunath
    Singh Gurpremjit
    Singh Devender
    Vyas Surabhi
    Arumugaswamy Prasanna Ramana
    V. Sreenivas
    S. K. Aggarwal
    Indian Journal of Surgery, 2021, 83 : 920 - 925
  • [50] Post-operative analgesic effect of intraperitoneal ropivacaine with or without tramadol in laparoscopic cholecystectomy
    Kumari, Anshu
    Acharya, Binita
    Ghimire, Bikal
    Shrestha, Anil
    INDIAN JOURNAL OF ANAESTHESIA, 2020, 64 (01) : 43 - 48