Optimal Post-Operative Nalbuphine Dose Regimen: A Randomized Controlled Trial in Patients with Laparoscopic Cholecystectomy
被引:0
|
作者:
Chen, Guan-Yu
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Kaohsiung Med Univ, Coll Med, Dept Anesthesiol, Kaohsiung 807, TaiwanKaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Chen, Guan-Yu
[1
,2
]
Kuo, Kung-Kai
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung 807, TaiwanKaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Kuo, Kung-Kai
[3
]
Chuang, Shih-Chang
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung 807, TaiwanKaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Chuang, Shih-Chang
[3
]
Tseng, Kuang-Yi
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Kaohsiung Med Univ, Coll Med, Dept Anesthesiol, Kaohsiung 807, TaiwanKaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Tseng, Kuang-Yi
[1
,2
]
Wang, Shen-Nien
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung 807, TaiwanKaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Wang, Shen-Nien
[3
]
Chang, Wen-Tsan
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Surg, Div Gen & Digest Surg, Kaohsiung 807, TaiwanKaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Chang, Wen-Tsan
[3
]
Cheng, Kuang-, I
论文数: 0引用数: 0
h-index: 0
机构:
Kaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Kaohsiung Med Univ, Coll Med, Dept Anesthesiol, Kaohsiung 807, TaiwanKaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
Cheng, Kuang-, I
[1
,2
]
机构:
[1] Kaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Anesthesiol, Kaohsiung 807, Taiwan
laparoscopic cholecystectomy;
patient control analgesia;
post-operative pain;
nalbuphine;
PAIN;
APPENDECTOMY;
D O I:
10.3390/medicina60020195
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background and Objectives: Optimal opioid analgesia is an excellent analgesia that does not present unexpected adverse effects. Nalbuphine, acting on the opioid receptor as a partial mu antagonist and kappa agonist, is considered a suitable option for patients undergoing laparoscopic surgery. Therefore, we aim to investigate the appropriate dosage of nalbuphine for post-operative pain management in patients with laparoscopic cholecystectomy. Materials and Methods: Patients were randomly categorized into low, medium, and high nalbuphine groups. In each group, a patient control device for post-operative pain control was programed with a low (0.05 mg/kg), medium (0.10 mg/kg), or high (0.20 mg/kg) nalbuphine dose as a loading dose and each bolus dose with a lockout interval of 7 min and without background infusion. Primary and secondary outcomes included the post-operative pain scale and nalbuphine consumption, and episodes of post-operative opioid-related adverse events and satisfactory scores. Results: The low-dosage group presented a higher initial self-reported pain score in comparison to the other two groups for the two hours post-op (p = 0.039) but presented lower nalbuphine consumption than the other two groups for four hours post-op (p = 0.047). There was no significant difference in the analysis of the satisfactory score and adverse events. Conclusions: An appropriate administration of nalbuphine could be 0.1 to 0.2 mg/kg at the initial four hours; this formula could be modified to a lower dosage (0.05 mg/kg) in the post-operative management of laparoscopic cholecystectomy.
机构:
Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R China
Cao, Shuang-jiao
Wu, Wei-wei
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R China
Wu, Wei-wei
Zhang, Wei-yi
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R China
Zhang, Wei-yi
Zhu, Tao
论文数: 0引用数: 0
h-index: 0
机构:
Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R China
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Yan, Yun
Lei, Chong
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Anaesthesiol & Perioperat Med, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Lei, Chong
Su, Binxiao
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Su, Binxiao
Dong, Enxia
论文数: 0引用数: 0
h-index: 0
机构:
Jiaotong Univ, Affiliated Honghui Hosp, Dept Intens Care Unit, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Dong, Enxia
Wang, Guangming
论文数: 0引用数: 0
h-index: 0
机构:
Hosp NORINCO Grp, Dept Intens Care Unit, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Wang, Guangming
Li, Bin
论文数: 0引用数: 0
h-index: 0
机构:
Lanzhou Univ, Hosp 1, Dept Intens Care Unit, Lanzhou, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Li, Bin
Li, Xinyu
论文数: 0引用数: 0
h-index: 0
机构:
Xian Med Univ, Affiliated Hosp 2, Dept Intens Care Unit, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Li, Xinyu
Li, Aiguang
论文数: 0引用数: 0
h-index: 0
机构:
Aerosp Gen Hosp, Dept Intens Care Unit, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Li, Aiguang
Gan, Guifen
论文数: 0引用数: 0
h-index: 0
机构:
Qinghai Univ, Affiliated Hosp, Dept Intens Care Unit, Xining, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Gan, Guifen
Chen, Yu
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
Chen, Yu
Zhang, Xijing
论文数: 0引用数: 0
h-index: 0
机构:
Fourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R ChinaFourth Mil Med Univ, Xijing Hosp, Dept Intens Care Unit, Xian, Peoples R China
机构:
Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Rawal, Rounak B.
Deal, Allison M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Ctr Comprehens Canc, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Deal, Allison M.
Ebert, Charles S., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Ebert, Charles S., Jr.
Dhandha, Vishal H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Dhandha, Vishal H.
Mitchell, Candace A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Mitchell, Candace A.
Hang, Anna X.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Hang, Anna X.
Gore, Mitchell R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Gore, Mitchell R.
Senior, Brent A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Univ N Carolina, Ctr Comprehens Canc, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Senior, Brent A.
Zanation, Adam M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
Univ N Carolina, Ctr Comprehens Canc, Chapel Hill, NC 27599 USAUniv N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA