Antiviral effects of interferon-stimulated genes in bats

被引：7

作者：

Zhang, Dan ^{[1
]}

Irving, Aaron T. ^{[2
,3
,4
,5
]}

机构：

[1] Zhejiang Univ Univ Edinburgh Inst, Haining, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou 310009, Peoples R China

[3] Zhejiang Univ Univ Edinburgh Inst, Ctr Infect Immun & Canc, Haining, Peoples R China

[4] BIMET Biomed & Hlth Translat Res Ctr Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China

[5] Univ Edinburgh, Coll Med & Vet Med, Edinburgh, Scotland

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2023年 / 13卷

基金：

美国国家科学基金会;

关键词：

interferon pathway; bat; ISGs; IFN; antiviral; TOLL-LIKE RECEPTORS; BLACK FLYING FOX; RIG-I; MOLECULAR CHARACTERIZATION; INFLUENZA-VIRUS; EVOLUTION; ACTIVATION; EXPRESSION; ALPHA; TRANSCRIPTOMES;

D O I：

10.3389/fcimb.2023.1224532

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interferon pathway is the first line of defense in viral infection in all mammals, and its induction stimulates broad expression of interferon-stimulated genes (ISGs). In mice and also humans, the antiviral function of ISGs has been extensively studied. As an important viral reservoir in nature, bats can coexist with a variety of pathogenic viruses without overt signs of disease, yet only limited data are available for the role of ISGs in bats. There are multiple species of bats and work has begun deciphering the differences and similarities between ISG function of human/mouse and different bat species. This review summarizes the current knowledge of conserved and bat-specific-ISGs and their known antiviral effector functions.

引用

页数：11

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