Addition of Carboxylic Acids to gem-Difluoroalkenes for the Synthesis of gem-Difluoromethylenated Compounds

被引：3
|
作者：
Zong, Yuwei [1 ]
Tsui, Gavin Chit [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Chem, Hong Kong 999077, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 06期
关键词：
CATALYSIS; STRATEGY;
D O I：
10.1021/acs.orglett.4c00095
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We herein describe a straightforward protocol for the synthesis of carboxylic esters containing a gem-difluoromethylene unit. Readily available carboxylic acids can act as nucleophiles to add regioselectively to tetrasubstituted or trisubstituted beta,beta-difluoroacrylates (formal hydroacetoxylation) for the construction of RCO2-CF2 bonds. Thermal conditions are sufficient without the use of catalysts or additives.
引用
收藏
页码：1261 / 1264
页数：4
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