Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca2+ overload in Caenorhabditis elegans

被引：0
|
作者：
Wu, XinTong [1 ]
Seida, Miku [1 ]
Abe, Takaaki [2 ,3 ]
Higashitani, Atsushi [1 ]
机构：
[1] Tohoku Univ, Grad Sch Life Sci, Sendai 9808577, Japan
[2] Tohoku Univ, Div Med Sci, Grad Sch Biomed Engn, Sendai 9800872, Japan
[3] Tohoku Univ, Dept Clin Biol & Hormonal Regulat, Grad Sch Med, Sendai 9800872, Japan
来源：
NPJ AGING | 2023年 / 9卷 / 01期
基金：
美国国家卫生研究院;
关键词：
CRISTAE; MORPHOLOGY; SURVIVAL; CALCIUM; MA-5;
D O I：
10.1038/s41514-023-00116-2
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Mitochonic acid-5 ameliorates the pathophysiology of human mitochondrial-disease fibroblasts and Caenorhabditis elegans Duchenne muscular dystrophy and Parkinson's disease models. Here, we found that 10 & mu;M MA-5 attenuates the age-related decline in motor performance, loss of muscle mitochondria, and degeneration of dopaminergic neurons associated with mitochondrial Ca2+ overload in C. elegans. These findings suggest that MA-5 may act as an anti-aging agent against a wide range of neuromuscular dysfunctions in metazoans.
引用
收藏
页数：5
相关论文
共 50 条
  • [41] Cisd2 slows down liver aging and attenuates age-related metabolic dysfunction in male mice
    Huang, Yi-Long
    Shen, Zhao-Qing
    Huang, Chen-Hua
    Lin, Chao-Hsiung
    Tsai, Ting-Fen
    AGING CELL, 2021, 20 (12)
  • [42] Reversal of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels
    Norris, CM
    Halpain, S
    Foster, TC
    JOURNAL OF NEUROSCIENCE, 1998, 18 (09): : 3171 - 3179
  • [43] Age-related decline in charge movement and intracellular [Ca2+] in mouse skeletal muscle fibers.
    Wang, ZM
    Messi, ML
    Delbono, O
    BIOPHYSICAL JOURNAL, 2000, 78 (01) : 369A - 369A
  • [44] Age-related differences in the effects of halothane vs. sevoflurane on Ca2+ regulation in cardiac muscle
    Mantilla, CB
    Prakash, YS
    Hunter, LW
    Housmans, PR
    Sieck, GC
    BIOPHYSICAL JOURNAL, 1999, 76 (01) : A307 - A307
  • [45] Age-related propofol effects on myocardial contraction and intracellular Ca2+ dynamics of isolated rat hearts
    Oguchi, T
    Yamaguchi, T
    Kashimoto, S
    Furuya, A
    Masui, K
    ANESTHESIOLOGY, 2000, 93 (3A) : U171 - U171
  • [46] Mitochondrial Uncoupling Protein-2 Is a Putative Link Between Mitochondrial Dysfunction and Fibroblast Senescence in Age-Related Lung Fibrosis
    Rangarajan, S.
    Locy, M. L.
    Darley-Usmar, V.
    Zmijewski, J. W.
    Tuder, R. M.
    Eickelberg, O.
    Thannickal, V. J.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199
  • [47] The Mitochondrial Na+/Ca2+ Exchanger Inhibitor CGP37157 Preserves Muscle Structure and Function to Increase Lifespan and Healthspan in Caenorhabditis elegans
    Garcia-Casas, Paloma
    Alvarez-Illera, Pilar
    Gomez-Orte, Eva
    Cabello, Juan
    Fonteriz, Rosalba I.
    Montero, Mayte
    Alvarez, Javier
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [48] Astrocytes are more vulnerable than neurons to cellular Ca2+ overload induced by a mitochondrial toxin, 3-nitropropionic acid
    Fukuda, A
    Deshpande, SB
    Shimano, Y
    Nishino, H
    NEUROSCIENCE, 1998, 87 (02) : 497 - 507
  • [49] Age-related alterations in fertilization-induced Ca2+ oscillations depend on the genetic background of mouse oocytes
    Czajkowska, Katarzyna
    Walewska, Agnieszka
    Ishikawa, Takao
    Szczepanska, Katarzyna
    Ajduk, Anna
    BIOLOGY OF REPRODUCTION, 2020, 103 (05) : 986 - 999
  • [50] Age-related differences in Na+-dependent Ca2+ accumulation in rabbit hearts exposed to hypoxia and acidification
    Anderson, SE
    Liu, H
    Ho, HS
    Lewis, EJ
    Cala, PM
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2003, 284 (05): : C1123 - C1132
12345