Imbalanced single-cell data integration leads to loss of biological information

被引：0
|
作者：
Maan, Hassaan [1 ]
机构：
[1] Univ Toronto, Toronto, ON, Canada
来源：
NATURE BIOTECHNOLOGY | 2024年 / 42卷 / 12期
关键词：
D O I：
10.1038/s41587-023-02114-x
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The Iniquitate pipeline assessed the impacts of cell-type imbalance on single-cell RNA sequencing integration through perturbations to dataset balance. The results indicated that cell-type imbalance not only leads to loss of biological signal in the integrated space, but also can change the interpretation of downstream analyses after integration.
引用
收藏
页码：1802 / 1803
页数：2
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