Spatial clustering reveals immune hub interaction with reservoir of stem-like CD8 T cells and predicts immunotherapy response in lung cancer patients

被引:0
|
作者
Chen, Jonathan
Nieman, Linda
Spurrell, Maxwell
Gainor, Justin
Hacohen, Nir
机构
关键词
D O I
10.1158/1538-7445.AM2023-5784
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
5784
引用
收藏
页数:2
相关论文
共 50 条
  • [31] B-CELL THERAPY (BVAX) PROMOTES CD8 T CELLS' PERSISTENCE AND FUNCTION IN THE GLIOBLASTOMA MICROENVIRONMENT BY MAINTAINING THEIR STEM-LIKE FEATURES
    Wan, Hanxiao
    Hou, David
    Katz, Joshua
    Wang, Si
    Castro, Brandyn
    Chia, Tzu-Yi
    Cervantes, Gustavo Ignacio Vazquez
    Billingham, Leah
    Arrieta, Victor
    Han, Yu
    Lopez-Rosas, Aurora
    Zhang, Peng
    Miska, Jason
    Lee-Chang, Catalina
    NEURO-ONCOLOGY, 2023, 25
  • [32] PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors
    Gill, Amanda L.
    Wang, Peter H.
    Lee, Judong
    Hudson, William H.
    Ando, Satomi
    Araki, Koichi
    Hu, Yinghong
    Wieland, Andreas
    Im, Sejin
    Gavora, Autumn
    Medina, Christopher B.
    Freeman, Gordon J.
    Hashimoto, Masao
    Reiner, Steven L.
    Ahmed, Rafi
    SCIENCE IMMUNOLOGY, 2023, 8 (86)
  • [33] Gli1 expression in cancer stem-like cells predicts poor prognosis in patients with lung squamous cell carcinoma
    Cui, Yan
    Cui, Chun-ai
    Yang, Zhao-ting
    Ni, Wei-dong
    Jin, Yu
    Xuan, Yan-hua
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2017, 102 (02) : 347 - 353
  • [34] Stem cell-like memory CD8 T cells establish early in the acute response to Yellow Fever vaccination
    Fuertes, Marraco Silvia A.
    Bovay, Amandine
    Nassiri, Sina
    Maby-El Hajjami, Helene
    Ouertatani, Hajer
    Held, Werner
    Speiser, Daniel E.
    SWISS MEDICAL WEEKLY, 2018, 148 : 38S - 38S
  • [35] Higher CD4/CD8 ratio of pleural effusion predicts better survival for lung cancer patients receiving immune checkpoint inhibitors
    Po-Hsin Lee
    Tsung-Ying Yang
    Kun-Chieh Chen
    Yen-Hsiang Huang
    Jeng-Sen Tseng
    Kuo-Hsuan Hsu
    Yu-Chen Wu
    Ko-Jiunn Liu
    Gee-Chen Chang
    Scientific Reports, 11
  • [36] Higher CD4/CD8 ratio of pleural effusion predicts better survival for lung cancer patients receiving immune checkpoint inhibitors
    Lee, Po-Hsin
    Yang, Tsung-Ying
    Chen, Kun-Chieh
    Huang, Yen-Hsiang
    Jeng-Sen Tseng
    Hsu, Kuo-Hsuan
    Wu, Yu-Chen
    Liu, Ko-Jiunn
    Chang, Gee-Chen
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [37] An immunologic niche of antigen presenting cells and stem-like CD8+T-cells is present in non-small cell lung cancer brain metastases.
    Jansen, Caroline S.
    del Balzo, Luke
    Prabhu, Roshan
    Logan, Suzanna
    Chappa, Prasanthi
    Patel, Kirtesh
    Wilkinson, Scott
    Lake, Ross
    Shu, Hui-Kuo G.
    Zhong, Jim
    Dhere, Vishal
    Olson, Jeffrey
    Sowalsky, Adam G.
    Khan, Mohammad K.
    Kissick, Haydn T.
    Buchwald, Zachary S.
    CLINICAL CANCER RESEARCH, 2021, 27 (08)
  • [38] Baseline immune signature score of Tregs x HLA-DR+CD4+ T cells x PD1+CD8+ T cells predicts outcome to immunotherapy in cancer patients
    Mispelbaum, Rebekka
    Hattenhauer, Sandra Tessa
    Held, Stefanie Andrea Erika
    Brossart, Peter
    Heine, Annkristin
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [39] The influence of the metabolic phenotype of CD8+T cells on immunotherapy response in patients with non-small cell lung cancer (NSCLC)
    Tan, Sze Ying
    Kearney, Ella
    Flanagan, Saoirse
    O'Reilly, David
    Naidoo, Jarushka
    Dowling, Catriona
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2024, 54 : 788 - 788
  • [40] New insights on anti-tumor immunity of CD8+ T cells: cancer stem cells, tumor immune microenvironment and immunotherapy
    Lin, Yibin
    Song, Yifu
    Zhang, Yaochuan
    Li, Xiaodong
    Kan, Liang
    Han, Sheng
    JOURNAL OF TRANSLATIONAL MEDICINE, 2025, 23 (01)