Low-Temperature Layer-by-Layer Growth of Semiconducting Few-Layer γ-Graphyne to Exploit Robust Biocompatibility

The sp-hybridized carbon network in single- or few-layer.-graphyne (gamma-GY) has a polarized electron distribution, which can be crucial in overcoming biosafety issues. Here, we report the lowtemperature synthesis, electronic properties, and amyloid fibril nanostructures of electrostatic few-layer gamma-GY. ABC stacked gamma-GY is synthesized by layer-by-layer growth on a catalytic copper surface, exhibiting intrinsic p-type semiconducting properties in few-layer gamma-GY. Thickness-dependent electronic properties of.-GY elucidate interlayer interactions by electron doping between electrostatic layers and layer stacking-involved modulation of the band gap. Electrostatic few-layer.GY induces high electronic sensitivity and intense interaction with amyloid beta (i.e., A ss(40)) peptides assembling into elongated mature A ss(40) fibrils. Two-dimensional biocompatible nanostructures of A ss(40) fibrils/ few-layer gamma-GY enable excellent cell viability and high neuronal differentiation of living cells without external stimulation.