Impact of lymph node ratio and number of lymph node metastases on survival and recurrence in laryngeal squamous cell carcinoma

被引：6

作者：

Molteni, Gabriele ^{[1
,2
]}

Nocini, Riccardo ^{[2
]}

Mattioli, Francesco ^{[3
]}

Nakayama, Meijin ^{[4
]}

Dedivitis, Rogerio A. ^{[5
]}

Mannelli, Giuditta ^{[6
]}

Crosetti, Erika ^{[7
]}

Chiesa-Estomba, Carlos Miguel ^{[8
]}

Sistiaga-Suarez, Jon A. ^{[9
]}

Giordano, Leone ^{[10
]}

Galli, Andrea ^{[10
]}

Lionello, Marco ^{[11
]}

Mercante, Giuseppe ^{[12
,13
]}

Ralli, Massimo ^{[14
]}

Fermi, Matteo ^{[15
,16
]}

Klein-Rodriguez, Alejandro ^{[17
]}

Mayo-Yanez, Miguel ^{[17
]}

Serafini, Edoardo ^{[3
]}

Pirola, Francesca ^{[13
]}

Paderno, Alberto ^{[18
]}

Cambria, Francesca ^{[14
]}

Oridate, Nobuhiko ^{[19
]}

Sano, Daisuke ^{[19
]}

Boscolo-Rizzo, Paolo ^{[20
]}

Marcuzzo, Alberto Vito ^{[20
]}

Parrinello, Giampiero ^{[21
]}

Marchi, Filippo ^{[21
,22
]}

Saibene, Alberto Maria ^{[23
]}

Tucciarone, Manuel ^{[24
]}

Viscasillas, Guillem ^{[25
]}

Zelenik, Karol ^{[26
]}

Ramos, Daniel Marin ^{[27
]}

Palacios-Garcia, Jose ^{[28
]}

Tirelli, Giancarlo ^{[20
]}

Pellini, Raul ^{[29
]}

Paludetti, Gaetano ^{[30
,31
]}

Galli, Jacopo ^{[30
,31
]}

Rossi, Giorgia ^{[30
,31
]}

De Vincentiis, Marco

Cernea, Claudio Roberto ^{[32
]}

Spriano, Giuseppe ^{[12
]}

Bussi, Mario ^{[10
]}

Peretti, Giorgio ^{[21
,22
]}

Succo, Giovanni ^{[33
]}

Piazza, Cesare

Bertolin, Andy ^{[11
]}

Kowalski, Luiz Paulo ^{[32
]}

Presutti, Livio ^{[15
,16
]}

Sacchetto, Andrea ^{[2
]}

机构：

[1] Univ Hosp Verona, Dept Otolaryngol Head & Neck Surg, Verona, Italy

[2] Univ Verona, Dept Surg Dent & Pediat, Unit Otolaryngol, Verona, Italy

[3] Univ Hosp Modena, Dept Otorhinolaryngol Head & Neck Surg, Modena, Italy

[4] Yokosuka Kyosai Hosp, Dept Otolaryngol, Yokohama, Japan

[5] Univ Sao Paulo, Dept Head & Neck Surg, Sch Med, Sao Paulo, Brazil

[6] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[7] Univ Turin, San Luigi Gonzaga Hosp, Dept Otorhinolaryngol, Turin, Italy

[8] Deusto Univ, Donostia Univ Hosp, Biodonostia Res Inst, Fac Med,Dept Otolaryngol Head & Neck Surg, San Sebastian, Spain

[9] Donostia Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, San Sebastian, Spain

[10] Univ Vita Salute San Raffaele, San Raffaele Sci Inst, Dept Otolaryngol Head & Neck Surg, Milan, Italy

[11] Vittorio Veneto Hosp, Unit Otorhinolaryngol, Vittorio Veneto, Italy

[12] IRCSS Humanitas Res Hosp, Unit Otorhinolaryngol, Milan, Italy

[13] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[14] Sapienza Univ Rome, Dept Sense Organs, Rome, Italy

[15] IRCCS Azienda Osped Univ Bologna, Dept Otorhinolaryngol Head & Neck Surg, Bologna, Italy

[16] Univ Bologna, Dept Specialist Diagnost & Expt Med DIMES, Alma Mater Studiorum, Bologna, Italy

[17] Complexo Hosp Univ Coruna, Dept Otorhinolaryngol Head & Neck Surg, La Coruna, Spain

[18] Univ Brescia, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, Unit Otorhinolaryngol Head & Neck Surg, ASST Spedali Civili Brescia, Brescia, Italy

[19] Yokohama City Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, Yokohama, Japan

[20] Univ Trieste, Dept Med Surg & Hlth Sci, Sect Otolaryngol, Trieste, Italy

[21] IRCCS Osped Policlin San Martino, Dept Otorhinolaryngol Head & Neck Surg, Genoa, Italy

[22] Univ Genoa, Dept Surg Sci & Integrated Diagnost DISC, Genoa, Italy

[23] Univ Milan, St Paolo & Carlo Hosp, Dept Hlth Sci, Unit Otolaryngol, Milan, Italy

[24] Univ Hosp Jerez, Dept Otorhinolaryngol, Cadiz, Spain

[25] Xarxa Assitencial Univ Manresa, Dept Otolaryngol Head & Neck, Althaia, Barcelona, Spain

[26] Univ Hosp Ostrava, Dept Otorhinolaryngol Head & Neck Surg, Ostrava, Czech Republic

[27] Canc Inst Sao Paulo ICESP, Dept Head & Neck Surg, Sao Paulo, Brazil

[28] Hosp Univ Virgen Macarena, Dept Otorhinolaryngol Head & Neck Surg, Seville, Spain

[29] IRCCS Regina Elena Natl Canc Inst, Dept Otolaryngol Head & Neck Surg, Rome, Italy

[30] Fdn Policlin Univ A Gemelli IRCCS, Unit Otorhinolaryngol, Rome, Italy

[31] Univ Cattolica Sacro Cuore, Dept Head & Neck & Sensory Organs, Rome, Italy

[32] Univ Sao Paulo, Dept Head & Neck Surg, Med Sch, Sao Paulo, Brazil

[33] San Giovanni Bosco Hosp, Unit Otolaryngol Head & Neck Surg, Turin, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2023年 / 45卷 / 09期

关键词：

laryngeal cancer; lymph node; lymph node metastasis; lymph node ratio; oncology; INDEPENDENT PREDICTOR; CANCER; NECK; HEAD; DENSITY; HYPOPHARYNGEAL; PREVALENCE; SUPERIOR;

D O I：

10.1002/hed.27471

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

IntroductionThe aim of this study is to assess the impact of lymph node ratio (LNR) and number of positive lymph nodes (NPLN) on mortality and recurrence rates in patients with laryngeal squamous cell carcinoma. Materials and methodsWe conducted a retrospective multicenter international study involving 24 Otorhinolaryngology-Head and Neck Surgery divisions. Disease-specific survival (DSS) and disease-free survival (DFS) were evaluated as the main outcomes. The curves for DSS and DFS according to NPLN and LNR were analyzed to identify significant variations and establish specific cut-off values. Results2507 patients met the inclusion criteria. DSS and DFS were significantly different in the groups of patients stratified according to LNR and NPLN. The 5-year DSS and DFS based on LNR and NPLN demonstrated an improved ability to stratify patients when compared to pN staging. ConclusionOur data demonstrate the potential prognostic value of NPLN and LNR in laryngeal squamous cell carcinoma.

引用

页码：2274 / 2293

页数：20

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