Exosome nanovesicles: A potential carrier for therapeutic delivery

被引:53
|
作者
Chavda, Vivek P. [1 ,11 ]
Pandya, Anjali [2 ,5 ]
Kumar, Lalit [3 ,6 ]
Raval, Nidhi [4 ]
Vora, Lalitkumar K. [5 ]
Pulakkat, Sreeranjini [2 ]
Patravale, Vandana [2 ]
Duo, Yanhong [7 ,8 ]
Tang, Ben Zhong [9 ,10 ]
机构
[1] L M Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, Ahmadabad 380009, India
[2] Inst Chem Technol, Dept Pharmaceut Sci & Technol, Mumbai 400019, India
[3] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut, Hajipur 844102, Bihar, India
[4] Univ British Columbia, Pharmaceut Sci Bldg,2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
[5] Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, North Ireland
[6] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Udupi 576104, Karnataka, India
[7] Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Radiat Oncol,Affiliated Hosp 1,Clin Med Coll, Shenzhen 518020, Peoples R China
[8] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden
[9] Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Hong Kong Branch, Kowloon, Clear Water Bay, Hong Kong, Peoples R China
[10] Hong Kong Univ Sci & Technol, Inst Adv Study, Kowloon, Clear Water Bay, Hong Kong 999077, Peoples R China
[11] LM Coll Pharm, Dept Pharmaceut, Ahmadabad 380009, Gujarat, India
关键词
Exosomes; Diagnosis; Therapeutics; Theranostics; Surface engineering; Etc; DRUG-DELIVERY; EXTRACELLULAR VESICLES; DIAGNOSTIC BIOMARKERS; ENGINEERING EXOSOMES; PROSTATE-CANCER; IN-VITRO; PROTEIN; CELLS; PLANT; MICROVESICLES;
D O I
10.1016/j.nantod.2023.101771
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Exosomes are small nanosized biovesicles that form when multivesicular bodies and the plasma membrane fuse and are released into the surrounding body fluids. They are best known for their multifunction in mediating intercellular communication by transferring various biomolecules, including DNA, RNAs, pro-teins, and lipids, in a short-and long-distance manner and have been identified as health and disease messengers. Importantly, exosomes are necessary for various physiological processes in health and disease. The generation of exosomes depends on the status of the disease, which usually exhibits opposite roles by inducing enhanced cellular stress and damage. Recently, exosome-based nanotechnologies have provided unprecedented opportunities to boost the developments of exosome-related biology, chemistry, pathology, and therapeutics in different diseases based on their unique structural/compositional/morphological characteristics for next-generation nanomedicines. Herein, we provide a comprehensive overview of the recent advances in exosome nanotechnology research, including their classification, isolation and pre-paration, constitution, biological function, and nanobiomedical applications in disease treatment and di-agnosis. Furthermore, future prospects were also concluded. This review will provide more inspiration for promoting the development of exosome-based advanced theranostic nanoplatforms and nanotechnology.(c) 2023 Published by Elsevier Ltd.
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页数:24
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