Neurophysiological characterization of stroke recovery: A longitudinal TMS and EEG study

被引:2
|
作者
Ding, Qian [1 ,2 ,3 ]
Chen, Jixiang [1 ]
Zhang, Shunxi [1 ]
Chen, Songbin [1 ]
Li, Xiaotong [1 ]
Peng, Yuan [1 ]
Chen, Yujie [1 ]
Chen, Junhui [1 ]
Chen, Kang [1 ]
Cai, Guiyuan [1 ]
Xu, Guangqing [2 ,4 ]
Lan, Yue [1 ,3 ,5 ]
机构
[1] South China Univ Technol, Guangzhou Peoples Hosp 1, Dept Rehabil Med, Guangzhou, Peoples R China
[2] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Rehabil Med, Guangzhou, Peoples R China
[3] Guangzhou Key Lab Aging Frailty & Neurorehabil, Guangzhou, Peoples R China
[4] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Rehabil Med, 106,Zhongshan Rd 2, Guangzhou 510080, Peoples R China
[5] South China Univ Technol, Affiliated Hosp 2, Sch Med, Dept Rehabil Med, 1 Panfu Rd, Guangzhou 510180, Peoples R China
基金
中国国家自然科学基金;
关键词
EEG; functional connectivity; stroke recovery; TMS; TRANSCRANIAL MAGNETIC STIMULATION; FUNCTIONAL CONNECTIVITY; MOTOR RECOVERY; CONTRALESIONAL HEMISPHERE; REORGANIZATION; PLASTICITY; PROVIDES;
D O I
10.1111/cns.14471
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Aims: Understanding the neural mechanisms underlying stroke recovery is critical to determine effective interventions for stroke rehabilitation. This study aims to systematically explore how recovery mechanisms post-stroke differ between individuals with different levels of functional integrity of the ipsilesional corticomotor pathway and motor function. Methods: Eighty-one stroke survivors and 15 age-matched healthy adults participated in this study. We used transcranial magnetic stimulation (TMS), electroencephalography (EEG), and concurrent TMS-EEG to investigate longitudinal neurophysiological changes post-stroke, and their relationship with behavioral changes. Subgroup analysis was performed based on the presence of paretic motor evoked potentials and motor function. Results: Functional connectivity was increased dramatically in low-functioning individuals without elicitable motor evoked potentials (MEPs), which showed a positive effect on motor recovery. Functional connectivity was increased gradually in higher-functioning individuals without elicitable MEP during stroke recovery and influence from the contralesional hemisphere played a key role in motor recovery. In individuals with elicitable MEPs, negative correlations between interhemispheric functional connectivity and motor function suggest that the influence from the contralesional hemisphere may be detrimental to motor recovery. Conclusion: Our results demonstrate prominent clinical implications for individualized stroke rehabilitation based on both functional integrity of the ipsilesional corticomotor pathway and motor function.
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收藏
页数:11
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