Ru(II)-Catalyzed Selective C-H Alkynylation of Isoquinolones, Quinazolones and Phthalazinones with Bromoalkynes

被引：2
|
作者：
Luo, Quan-Jian [1 ]
Wang, Han-Chi [1 ]
Zhang, Jing [1 ]
Li, Jin-Heng [1 ,2 ,3 ]
Sun, Bo [1 ]
机构：
[1] Qingdao Univ Sci & Technol, Coll Chem Engn, State Key Lab Base Ecochem Engn, Qingdao 266042, Shandong, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2024年 / 42卷 / 15期
关键词：
Ru(II); Alkynylation; Isoquinolones; Bromoalkynes; Heterocyclic compounds; C-H activation; C-C coupling; Synthetic methods; ARENES; COORDINATION; ANNULATION;
D O I：
10.1002/cjoc.202400107
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new, selective Ru(II)-catalyzed alkynylation reaction of isoquinolones, quinazolones and phthalazinones with readily available bromoalkynes has been developed. This reaction enables the selective construction of a new C(sp(2))-C(sp) bond through C-H activation and C-Br functionalization, and offers an effective and selective route to synthesizing highly valuable alkynylated isoquinolone, quinazolone and phthalazinone derivatives with a wide substrate scope and high selectivity.
引用
收藏
页码：1686 / 1690
页数：5
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