Cognitive and gait in Wilson's disease: a cognitive and motor dual-task study

被引:1
|
作者
Wang, Gongqiang [1 ,2 ]
Jin, Ping [2 ]
Ma, Xinfeng [2 ]
Hong, Xia [3 ]
Zhang, Long [2 ]
Lin, Kang [2 ]
Wen, Xiao [3 ]
Bai, Xue [3 ]
Han, Yongzhu [1 ,2 ]
机构
[1] Anhui Univ Tradit Chinese Med, Inst Neurol, Hefei, Peoples R China
[2] Anhui Univ Tradit Chinese Med, Affiliated Hosp, Inst Neurol, Hefei, Peoples R China
[3] Anhui Univ Tradit Chinese Med, Grad Sch, Hefei, Peoples R China
来源
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词
Wilson ' s disease; cognitive impairment; gait disturbance; dual task; cognitive and gait; FALLS; PERFORMANCE; MOBILITY; GO;
D O I
10.3389/fneur.2023.1243122
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Cognitive and motor dual-tasks play important roles in daily life. Dual-task interference impacting gait performance has been observed not only in healthy subjects but also in subjects with neurological disorders. Approximately 44-75% of Wilson ' s disease (WD) patients have gait disturbance. According to our earlier research, 59.7% of WD patients have cognitive impairment. However, there are few studies on how cognition affects the gait in WD. Therefore, this study aims to explore the influence of cognitive impairment on gait and its neural mechanism in WD patients and to provide evidence for the clinical intervention of gait disturbance. Methods: We recruited 63 patients who were divided into two groups based on their scores on the Addenbrooke ' s cognitive examination III (ACE-III) scale: a non-cognitive impairment group and a cognitive impairment group. In addition to performing the timed up and go (TUG) single task and the cognitive and motor dual-task digital calculation and animal naming tests, the Tinetti Balance and Gait Assessment (POMA), Berg Balance Scale (BBS), and brain MRI severity scale of WD (bMRIsc-WD) were evaluated. The dual-task cost (DTC) was also computed. Between the two groups, the results of the enhanced POMA, BBS, and bMRIscWD scales, as well as gait performance measures such as TUG step size, pace speed, pace frequency, and DTC value, were compared. Results: (1) Among the 63 patients with WD, 30 (47.6%) patients had gait disturbance, and the single task TUG time was more than 10 s. A total of 43 patients had cognitive impairment, the incidence rate is 44.4%. Furthermore, 28 (44.4%) patients had cognitive impairment, 39 (61.9%) patients had abnormal brain MRI. (2) The Tinetti gait balance scale and Berg balance scale scores of patients with cognitive impairment were lower than those of patients without cognitive impairment (p < 0.05), and the pace, step size, and pace frequency in the single task TUG were slower than those of patients without cognitive impairment (p < 0.05). There was no change in the pace frequency between the dual-task TUG and the non-cognitive impairment group, but the pace speed and step size in the dual-task TUG were smaller than non-cognitive impairment group (p < 0.05). There was no difference in DTC values between cognitive impairment group and non-cognitive impairment group when performing dt-TUG number calculation and animal naming respectively (p > 0.05). However, regardless of cognitive impairment or not, the DTC2 values of number calculation tasks is higher than DTC1 of animal naming tasks in dt-TUG (p < 0.05). (3) Pace speed and step size were related to the total cognitive score, memory, language fluency, language understanding, and visual space factor score of the ACE-III (p < 0.05), and step frequency was correlated with memory and language comprehension factors (p < 0.05). There was no correlation between the attention factor scores of the ACE-III and TUG gait parameters of different tasks (p > 0.05). Brain atrophy, the thalamus, caudate nucleus, and cerebellum were correlated with cognitive impairment (p < 0.05), the lenticular nucleus was related to the step size, brain atrophy was related to the pace speed, and the thalamus, caudate nucleus, and midbrain were involved in step frequency in WD patients (p < 0.05). Conclusion: WD patients had a high incidence of cognitive impairment and gait disorder, the pace speed and step size can reflect the cognitive impairment of WD patients, cognitive impairment affects the gait disorder of WD patients, and the different cognitive and motor dual-tasks were involved in affecting gait parameters. The joint participation of cognitive impairment and lesion brain area may be the principal neural mechanism of gait abnormality in WD patients.
引用
收藏
页数:9
相关论文
共 50 条
  • [21] The effects of dual-task in patients with Parkinson's disease performing cognitive-motor paradigms
    Hsiu-Chen, Chang
    Chiung-Chu, Chen
    Jiunn-Woei, Liaw
    Wei-Da, Chiou
    Yi-Hsin, Weng
    Ya-Ju, Chang
    Chin-Song, Lu
    JOURNAL OF CLINICAL NEUROSCIENCE, 2020, 72 : 72 - 78
  • [22] Gait Indicators Contribute to Screening Cognitive Impairment: A Single- and Dual-Task Gait Study
    Wang, Xiaoqin
    Yu, Wuhan
    Huang, Lihong
    Yan, Mengyu
    Zhang, Wenbo
    Song, Jiaqi
    Liu, Xintong
    Yu, Weihua
    Lu, Yang
    BRAIN SCIENCES, 2023, 13 (01)
  • [23] Using dual-task gait to recognize Alzheimer's disease and mild cognitive impairment: a cross-sectional study
    Li, Zhaoying
    Zhu, Jingyi
    Liu, Junyan
    Shi, Min
    Liu, Pan
    Guo, Junjie
    Hu, Zhenzhu
    Liu, Shanyu
    Yang, Dongdong
    FRONTIERS IN HUMAN NEUROSCIENCE, 2023, 17
  • [24] The effect of different cognitive domains on dual-task cost of gait in cognitive impaired elderly
    Lamoth, Claudine
    Van Campen, Jos
    Appels, Bregje
    INTERNATIONAL PSYCHOGERIATRICS, 2013, 25 : S59 - S60
  • [25] Cognitive-motor dual-task interference in adults with sickle cell disease
    Subramaniam, Arvind P.
    Oyedeji, Charity I.
    Parikh, Jhana S.
    Feld, Jody A.
    Strouse, John J.
    GAIT & POSTURE, 2023, 102 : 164 - 170
  • [26] Dual-task Interference Disrupts Parkinson's Gait Across Multiple Cognitive Domains
    Penko, Amanda L.
    Streicher, Matthew C.
    Koop, Mandy Miller
    Dey, Tanujit
    Rosenfeldt, Anson B.
    Bazyk, Andrew S.
    Alberts, Jay L.
    NEUROSCIENCE, 2018, 379 : 375 - 382
  • [27] COGNITIVE TRAINING AND MOTOR DUAL-TASK ABILITY IN OLDER ADULTS: A PRELIMINARY STUDY
    Hall, C.
    Sesay, M.
    Echt, K.
    GERONTOLOGIST, 2016, 56 : 395 - 395
  • [28] Dual-task interference as a function of varying motor and cognitive demands
    McPhee, Anna Michelle
    Cheung, Theodore C. K.
    Schmuckler, Mark A.
    FRONTIERS IN PSYCHOLOGY, 2022, 13
  • [29] DUAL-TASK TRAINING FOR IMPROVING COGNITIVE-MOTOR INTERFERENCE
    Bhatt, Tanvi
    Kannan, Lakshmi
    INNOVATION IN AGING, 2022, 6 : 394 - 394
  • [30] Gait And Cognitive Assessments Of Concussed Athletes During Dual-task Walking
    Ake, Klarie M.
    D'Amico, Nathan R.
    Grimes, Katelyn E.
    Mormile, Megan E.
    Powell, Douglas W.
    Buckley, Thomas A. A.
    Munkasy, Barry A.
    Murray, Nicholas G.
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2016, 48 (05): : 815 - 815