The emerging role of lncRNAs in osteoarthritis development and potential therapy

被引：4
|
作者：
Zhang, Xiaofeng [1 ]
Liu, Qishun [2 ]
Zhang, Jiandong [3 ]
Song, Caiyuan [1 ]
Han, Zongxiao [1 ]
Wang, Jinjie [1 ]
Shu, Lilu [4 ]
Liu, Wenjun [4 ]
He, Jinlin [1 ]
Wang, Peter [4 ]
机构：
[1] Hangzhou Fuyang Hosp TCM Orthoped & Traumatol, Dept Traumatol, Hangzhou, Zhejiang, Peoples R China
[2] Hang Gang Hosp, Zhejiang Med & Hlth Grp Hangzhou Hosp, Dept Orthoped, Hangzhou, Peoples R China
[3] Hangzhou Fuyang Hosp TCM Orthoped & Traumatol, Dept Orthoped & Traumatol, Hangzhou, Zhejiang, Peoples R China
[4] Zhejiang Zhongwei Med Res Ctr, Dept Med, Hangzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN GENETICS | 2023年 / 14卷
关键词：
osteoarthritis; noncoding RNA; lncRNA; biomarkers; treatment; CHONDROCYTE EXTRACELLULAR-MATRIX; LONG NONCODING RNAS; COMPETING ENDOGENOUS RNA; ARTICULAR CHONDROCYTES; KNEE OSTEOARTHRITIS; INTERLEUKIN-1-BETA-INDUCED INFLAMMATION; PROMOTES PROLIFERATION; INHIBITS APOPTOSIS; EXPRESSION PROFILE; CARTILAGE INJURY;
D O I：
10.3389/fgene.2023.1273933
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Osteoarthritis impairs the functions of various joints, such as knees, hips, hands and spine, which causes pain, swelling, stiffness and reduced mobility in joints. Multiple factors, including age, joint injuries, obesity, and mechanical stress, could contribute to osteoarthritis development and progression. Evidence has demonstrated that genetics and epigenetics play a critical role in osteoarthritis initiation and progression. Noncoding RNAs (ncRNAs) have been revealed to participate in osteoarthritis development. In this review, we describe the pivotal functions and molecular mechanisms of numerous lncRNAs in osteoarthritis progression. We mention that long noncoding RNAs (lncRNAs) could be biomarkers for osteoarthritis diagnosis, prognosis and therapeutic targets. Moreover, we highlight the several compounds that alleviate osteoarthritis progression in part via targeting lncRNAs. Furthermore, we provide the future perspectives regarding the potential application of lncRNAs in diagnosis, treatment and prognosis of osteoarthritis.
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页数：16
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