Case report: Hyponatremia is an initial presentation of Neuromyelitis optica spectrum disorder

被引:0
|
作者
Meng, Huaxing [1 ]
Wang, Jing [1 ]
Hou, Jiaqi [1 ]
Liu, Ruiqin [1 ]
Zhang, Meini [1 ,2 ]
机构
[1] Shanxi Med Univ, Dept Neurol, Hosp 1, Taiyuan, Shanxi, Peoples R China
[2] Shanxi Med Univ, Dept neurol, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China
关键词
Neuromyelitis optica spectrum disorder; hyponatremia; aquaporin; 4; acute diencephalon syndrome; SIADH;
D O I
10.1080/00207454.2023.2277666
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
ObjectiveNeuromyelitis optica spectrum disorders (NMOSD) is often misdiagnosed or delayed because of the complex and diverse clinical manifestations, especially the atypical initial presentation. Hyponatremia can be an infrequently isolated initial presentation of NMOSD and is associated with hypothalamus involvement. Awareness of this mechanism will help clinicians to identify NMOSD early, treat it in time and improve the prognosis.MethodsWe describe a 36-year-old woman who developed repeated hyponatremia and then experienced diplopia. Serum AQP4, MOG, MBP and GFAP antibody were detected, and NMOSD was finally diagnosed.ResultsShe responded well to high-dose glucocorticoids. Sequential treatment with mycophenolate mofetil (MMF) was prescribed. Two-month follow-up revealed full recovery. So far, after 10 months, the patient still has no recurrence.ConclusionFor young patients, repeated hyponatremia, with or without slight fever, and no evidence of obvious infection, brain magnetic resonance imaging (MRI) and serum AQP4/MOG antibody detection may be useful to determine whether there is a possibility of NMOSD.
引用
收藏
页码:1399 / 1402
页数:4
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