PHARMACOKINETICS (PK) OF HZN-825, A SMALL MOLECULE SELECTIVE ANTAGONIST OF LPAR1, AND THE EFFECT OF FOOD IN HEALTHY ADULT SUBJECTS

被引：0
|
作者：
Song, Y. [1 ]
Ali, F. [2 ]
Ye, Z. [2 ]
Zarzoso, J. [1 ]
Rogowski, J. [1 ]
Sun, Y. [1 ]
Xin, Y. [1 ]
机构：
[1] Horizon Therapeut, San Francisco, CA USA
[2] Horizon Therapeut, Chicago, IL USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2023年 / 113卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
PII-071
引用
收藏
页码：S66 / S67
页数：2
相关论文
共 50 条
  • [21] Safety, Pharmacokinetics, and Food Effect of Tebipenem Pivoxil Hydrobromide after Single and Multiple Ascending Oral Doses in Healthy Adult Subjects
    Eckburg, Paul B.
    Jain, Akash
    Walpole, Susannah
    Moore, Grayson
    Utley, Luke
    Manyak, Erika
    Dane, Aaron
    Melnick, David
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2019, 63 (09)
  • [22] Safety, Tolerability, and Pharmacokinetics of SC1011 (Sufenidone), a Novel Antifibrotic Small Molecule, in Phase 1 Studies in Healthy Subjects
    Liu, Yun
    Chen, Xiaoning
    Tang, Huimin
    Jiang, Fan
    Tang, Yaqin
    Zhu, Huijuan
    Du, Yanping
    Qian, Hongjie
    Liu, Shuyun
    Sun, Xiaoshu
    Zan, Bin
    Zeng, Yuexia
    Li, Yun
    Ge, Zhen
    Li, Yongguo
    Yang, Zhongqi
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2025, 18 (03):
  • [23] Pharmacokinetics and food-effect of fosdagrocorat (PF-04171327), a dissociated agonist of the glucocorticoid receptor, in healthy adult Caucasian and Japanese subjects
    Miyoshi, So
    Hey-Hadavi, Judith
    Nagaoka, Makoto
    Tammara, Brinda
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2016, 54 (12) : 966 - 976
  • [24] A Phase 1, Open-Label Study to Evaluate the Effects of Food and Evening Dosing on the Pharmacokinetics of Oral Trofinetide in Healthy Adult Subjects
    Darwish, Mona
    Youakim, James M.
    Harlick, Jim
    DeKarske, Daryl
    Stankovic, Serge
    CLINICAL DRUG INVESTIGATION, 2022, 42 (06) : 513 - 524
  • [25] A safety, tolerability, and pharmacokinetics (PK) study of single and multiple doses of lecozotan sustained release (SR), a novel S-HT1A antagonist, in healthy young subjects
    Raja, S.
    Parks, V.
    Plotka, A.
    Patas, A.
    Paul, J.
    Chalon, S.
    JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 48 (09): : 1121 - 1121
  • [26] A Phase 1, Open-Label Study to Evaluate the Effects of Food and Evening Dosing on the Pharmacokinetics of Oral Trofinetide in Healthy Adult Subjects
    Mona Darwish
    James M. Youakim
    Jim Harlick
    Daryl DeKarske
    Serge Stankovic
    Clinical Drug Investigation, 2022, 42 : 513 - 524
  • [27] Open label study to estimate the effect of fluconazole on the pharmacokinetics of a JAK3 antagonist (CP-690,550) in healthy adult subjects.
    Chow, V.
    Ni, G.
    LaBadie, R.
    Chan, G.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2008, 83 : S36 - S36
  • [28] NO SIGNIFICANT FOOD EFFECT ON THE PHARMACOKINETICS OF AZD6140, THE FIRST REVERSIBLE ORAL P2Y12 RECEPTOR ANTAGONIST, IN HEALTHY SUBJECTS
    Butler, K.
    Mitchell, P. D.
    Teng, R.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 85 : S20 - S20
  • [29] EFFECT OF MULTIPLE-DOSE SETIPIPRANT, A SELECTIVE ORAL CRTH2 ANTAGONIST, ON THE PHARMACOKINETICS OF SINGLE-DOSE SIMVASTATIN IN HEALTHY MALE SUBJECTS
    Gehin, M.
    Mackie, A.
    Sidharta, P. N.
    Kadlecova, P.
    Petersen-Sylla, M.
    Halabi, A.
    Dingemanse, J.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 93 : S42 - S42
  • [30] Safety, Pharmacokinetics, and Pharmacodynamics Study in Healthy Subjects of Oral NEO6860, a Modality Selective Transient Receptor Potential Vanilloid Subtype 1 Antagonist
    Brown, William
    Leff, Richard L.
    Griffin, Andrew
    Hossack, Stuart
    Aubray, Roxane
    Walker, Philippe
    Chiche, Dan A.
    JOURNAL OF PAIN, 2017, 18 (06): : 726 - 738
12345