Mild and highly efficient method for synthesis of 1,5-benzodiazepine using pentafluorobenzenaminium hexafluorophosphate as a novel organocatalyst

被引：2

作者：

Ghadiri, Seyede Khadije ^{[1
]}

Baghbanian, Seyed Meysam ^{[1
]}

Khaksar, Samad ^{[1
,2
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Ayatollah Amoli Branch, Amol, Iran

[2] Univ Georgia, Sch Sci & Technol, Tbilisi, Georgia

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2023年 / 1272卷

关键词：

5-Benzodiazepine; Organocatalyst; Pentafluorouaniline; Hexafluorophosphate; Phenylenediamine; LIQUID PROMOTED SYNTHESIS; ONE-POT SYNTHESIS; DERIVATIVES; CATALYST;

D O I：

10.1016/j.molstruc.2022.134057

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Organocatalyst are used in the synthesis of 1,5-benzodiazepines. In this study, a new method for the synthesis of 1,5-benzodiazepines was proposed by the reaction of 1,2-phenylenediamine, benzaldehyde derivatives, and diamidone in the presence of pentafluorobenzenaminium under mild conditions. The results show that products with high efficiency are obtained in a short time. In this project, first the optimal reaction conditions such as temperature, catalyst value, and the molar ratio of raw materials were examined, and then using optimized conditions 1,5-benzodiazepines were prepared. The advantages of this method are high product efficiency, short reaction time, and easy separation of products.(c) 2022 Elsevier B.V. All rights reserved.

引用

页数：5

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