Successful Treatment of Granulomatous-lymphocytic Interstitial Lung Disease in a Patient with CTLA-4 Deficiency

被引：2
|
作者：
Nishimura, Masashi
Miyata, Jun [1 ]
Tanigaki, Tomomi
Nomura, Sakika
Serizawa, Yusuke
Igarashi, Syunya
Itou, Koki
Ohno, Tomohiro
Kurata, Yuhei
Kimizuka, Yoshifumi
Fujikura, Yuji
Sekinaka, Yujin
Sekinaka, Kanako
Matsukuma, Susumu
Nonoyama, Shigeaki
Kawana, Akihiko
机构：
[1] Natl Def Med Coll, Dept Internal Med, Div Infect Dis & Resp Med, Tokorozawa, Japan
来源：
INTERNAL MEDICINE | 2023年 / 62卷 / 06期
关键词：
common variable immunodeficiency; corticosteroid; CTLA-4; deficiency; granulomatous-lymphocytic interstitial lung disease; video-assisted thoracoscopic surgery; COMMON VARIABLE IMMUNODEFICIENCY; DIAGNOSIS;
D O I：
10.2169/internalmedicine.0076-22
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Common variable immunodeficiency (CVID) causes granulomatous-lymphocytic interstitial lung disease (GLILD) and has a poor prognosis. We herein report a case of GLILD in a 49-year-old woman with CTLA-4 deficiency-associated CVID. The patient presented with dyspnea that had worsened over the past two years. A laboratory examination revealed hypoglobulinemia and pancytopenia. Chest computed tomography showed diffuse infiltrative and granular shadows in the bilateral interstitium. A flow cytometric analysis of blood cells and genetic testing confirmed CTLA-4 deficiency. We performed video-assisted thoracoscopic surgery for the pathological diagnosis of GLILD and to exclude infection and malignancy. Corticosteroid treatment successfully improved the condition of the patient.
引用
收藏
页码：871 / 875
页数：5
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