Clinical and pathophysiological implications of autoantibodies in autoimmune neuropathies

Autoimmune neuropathies are a heterogeneous group of rare and disabling diseases in which the immune system targets peripheral nervous system antigens and that respond to immune therapies. This review focuses on Guillain-Barresyndrome, chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, polyneuropathy associated with IgM monoclonal gammopathy, and autoimmune nodopathies. Autoantibodies targeting gangliosides, proteins in the node of Ranvier, and myelin-associated glycoprotein have been described in these disorders, defining subgroups of patients with similar clinical features and response to therapy. This topical review describes the role of these auto-antibodies in the pathogenesis of autoimmune neuropathies and their clinical and thera-peutic importance. # 2023 Elsevier Masson SAS. All rights reserved.