Plant-Derived Vesicle-Like Nanoparticles: Clinical Application Exploration and Challenges

被引：8
|
作者：
He, Wenfang [1 ]
Zheng, Siqiang [1 ]
Zhang, Hua [2 ]
Gao, Bowen [3 ]
Jin, Juan [1 ]
Zhang, Mingzhen [3 ,4 ]
He, Qiang [1 ]
机构：
[1] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Tradit Chinese Med, Dept Nephrol, Hangzhou 310000, Zhejiang, Peoples R China
[2] Hangzhou Med Coll, Hangzhou, Zhejiang, Peoples R China
[3] Xi An Jiao Tong Univ, Sch Basic Med Sci, Xian Key Lab Immune Related Dis, Xian 710061, Shaanxi, Peoples R China
[4] Xi An Jiao Tong Univ, Minist Educ, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2023年 / 18卷
关键词：
plant-derived vesicle-like nanoparticles; extraction methods; anti-inflammatory; immune regulation; antitumor; EXOSOME-LIKE NANOVESICLES; EXTRACELLULAR VESICLES; DRUG-DELIVERY; CHROMATOGRAPHY; OPPORTUNITY; PROGRESS; CELLS;
D O I：
10.2147/IJN.S428647
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The utilization of plant-derived vesicle-like nanoparticles (PDVLNs) has shown effectiveness in the prevention/treatment of inflammatory-mediated diseases, malignancies, and immune-related diseases, such as acute liver injury, allergic asthma, gastric cancer and so on. This highlights the promising potential of PDVLNs as biotherapeutics. Furthermore, it should be noted that PDVLNs possess the ability to function as both natural and engineered drug carriers, making them an appealing option. This review aims to present the appropriate extraction methods of PDVLNs, summarize the applications of PDVLNs in different diseases, and provide an outlook on the prospects of PDVLNs. At the same time, the authors also express their discussion on the current limitations of PDVLNs.
引用
收藏
页码：5671 / 5683
页数：13
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