Reincarnating autoimmunity: Immune-related adverse events as new diseases

Oncologists who give immunotherapy today have had to rediscover internal medicine all over again. After immune checkpoint inhibitor therapy has been started, and even after it has been stopped, immune-related adverse events (irAEs) can manifest in any organ at unpredictable times and can replicate any naturally occurring autoimmune disease. But while irAEs can mimic their naturally occurring counterparts, their presentations, the ideal immunosuppressive regimens to control them, and their durations are unique. As such, irAEs are a new class of autoimmune disorders whose optimal diagnosis, management, and treatment remain incompletely discovered and ripe for innovation. © 2023, Cleveland Clinic Journal of Medicine. All Rights Reserved.