Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia

被引：1
|
作者：
Botana, Iria Fernandez [1 ,2 ]
Pagano, Giulia [1 ,2 ]
Moussay, Etienne [1 ]
Paggetti, Jerome [1 ]
机构：
[1] Luxembourg Inst Hlth, Dept Canc Res, Tumor Stroma Interact, Strassen, Luxembourg
[2] Univ Luxembourg, Fac Sci Technol & Med, Esch Sur Alzette, Luxembourg
来源：
ONCOIMMUNOLOGY | 2023年 / 12卷 / 01期
关键词：
Cytokine; IL-27; CD8+T cells; immunotherapy; leukemia;
D O I：
10.1080/2162402X.2023.2276490
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.
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页数：3
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