Further undescribed cembranoids from South China Sea soft coral Sarcophyton ehrenbergi: Structural elucidation and biological evaluation

被引：3
|
作者：
Wu, Meng-Jun [1 ,2 ,3 ]
Yu, Dan-Dan [5 ,6 ]
Du, Ye-Qing [3 ]
Zhang, Juan [4 ]
Su, Ming-Zhi [6 ]
Jiang, Cheng-Shi [4 ]
Guo, Yue-Wei [1 ,2 ,3 ,5 ,6 ]
机构：
[1] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gre, Hangzhou 310014, Peoples R China
[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
[4] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Peoples R China
[5] Guangdong Med Univ, Coll Pharm, Zhanjiang 524023, Guangdong, Peoples R China
[6] Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
来源：
PHYTOCHEMISTRY | 2023年 / 206卷
关键词：
Sarcophyton ehrenbergi; Sarcophytidae; Soft coral; Diterpenoids; Cembranoid; -Glucosidase inhibitor; DITERPENOIDS; CHEMISTRY;
D O I：
10.1016/j.phytochem.2022.113549
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A detailed chemical investigation of the South China Sea soft coral Sarcophyton ehrenbergi has yield seven undescribed cembranoids, namely isoehrenbergol D and sarcoehrenolides F-K embodying a rare alpha,beta-unsaturated-lactone moiety at C-6 to C-19, along with two known related compounds, ehrenbergol D and sarcoehrenolide A. Their structures and absolute configurations were unambiguously established in the light of extensive spectro-scopic data analysis, modified Mosher's method, X-ray diffraction analysis, and quantum chemical computation method. In a bioassay for alpha-glucosidase inhibition, ehrenbergol D was evaluated as alpha-glucosidase inhibitor with an IC50 value of 13.57 mu M.
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页数：9
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