TUG-891 inhibits neuronal endoplasmic reticulum stress and pyroptosis activation and protects neurons in a mouse model of intraventricular hemorrhage

被引：5

作者：

Wang, Hao-Xiang ^{[1
]}

Liu, Chang ^{[2
]}

Li, Yuan-You ^{[1
]}

Cao, Yi ^{[3
]}

Zhao, Long ^{[4
]}

Zhao, Yan-Jie ^{[1
]}

Deng, Zi-Ang ^{[1
]}

Tong, Ai-Ping ^{[1
,5
]}

Zhou, Liang-Xue ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China

[3] Chengdu Second Peoples Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China

[4] North Sichuan Med Coll, Affiliated Hosp, Dept Neurosurg, Nanchong, Sichuan, Peoples R China

[5] Sichuan Univ, West China Med Sch, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2023年 / 18卷 / 10期

关键词：

ameliorating inflammation; endoplasmic reticulum stress; GPR120; GSDMD; hemorrhagic stroke; neurological function; NLRP3; pyroptosis; TUG-891; unfolded protein response; CELL-DEATH; INTRACEREBRAL HEMORRHAGE; INFLAMMASOME ACTIVATION; GASDERMIN D; ER STRESS; GPR120;

D O I：

10.4103/1673-5374.369116

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pyroptosis plays an important role in hemorrhagic stroke. Excessive endoplasmic reticulum stress can cause endoplasmic reticulum dysfunction and cellular pyroptosis by regulating the nucleotide-binding oligomerization domain and leucine-rich repeat pyrin domain-containing protein 3 (NLRP3) pathway. However, the relationship between pyroptosis and endoplasmic reticulum stress after intraventricular hemorrhage is unclear. In this study, we established a mouse model of intraventricular hemorrhage and found pyroptosis and endoplasmic reticulum stress in brain tissue. Intraperitoneal injection of the selective GPR120 agonist TUG-891 inhibited endoplasmic reticulum stress, pyroptosis, and inflammation and protected neurons. The neuroprotective effect of TUG-891 appears related to inhibition of endoplasmic reticulum stress and pyroptosis activation.

引用

页码：2278 / 2284

页数：7

共 29 条

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