TUG-891 inhibits neuronal endoplasmic reticulum stress and pyroptosis activation and protects neurons in a mouse model of intraventricular hemorrhage

被引：5
|
作者：
Wang, Hao-Xiang [1 ]
Liu, Chang [2 ]
Li, Yuan-You [1 ]
Cao, Yi [3 ]
Zhao, Long [4 ]
Zhao, Yan-Jie [1 ]
Deng, Zi-Ang [1 ]
Tong, Ai-Ping [1 ,5 ]
Zhou, Liang-Xue [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China
[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurosurg, Chongqing, Peoples R China
[3] Chengdu Second Peoples Hosp, Dept Neurosurg, Chengdu, Sichuan, Peoples R China
[4] North Sichuan Med Coll, Affiliated Hosp, Dept Neurosurg, Nanchong, Sichuan, Peoples R China
[5] Sichuan Univ, West China Med Sch, State Key Lab Biotherapy, Chengdu, Sichuan, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2023年 / 18卷 / 10期
关键词：
ameliorating inflammation; endoplasmic reticulum stress; GPR120; GSDMD; hemorrhagic stroke; neurological function; NLRP3; pyroptosis; TUG-891; unfolded protein response; CELL-DEATH; INTRACEREBRAL HEMORRHAGE; INFLAMMASOME ACTIVATION; GASDERMIN D; ER STRESS; GPR120;
D O I：
10.4103/1673-5374.369116
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pyroptosis plays an important role in hemorrhagic stroke. Excessive endoplasmic reticulum stress can cause endoplasmic reticulum dysfunction and cellular pyroptosis by regulating the nucleotide-binding oligomerization domain and leucine-rich repeat pyrin domain-containing protein 3 (NLRP3) pathway. However, the relationship between pyroptosis and endoplasmic reticulum stress after intraventricular hemorrhage is unclear. In this study, we established a mouse model of intraventricular hemorrhage and found pyroptosis and endoplasmic reticulum stress in brain tissue. Intraperitoneal injection of the selective GPR120 agonist TUG-891 inhibited endoplasmic reticulum stress, pyroptosis, and inflammation and protected neurons. The neuroprotective effect of TUG-891 appears related to inhibition of endoplasmic reticulum stress and pyroptosis activation.
引用
收藏
页码：2278 / 2284
页数：7
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