Temperature-Tuning Desorption Ionization for Ambient Mass Spectrometry

被引：5

作者：

Li, Ningxi ^{[1
]}

Cai, Zhijun ^{[1
]}

Zhang, Zhongyao ^{[1
]}

Zhang, Wenpeng ^{[1
]}

Ma, Xiaoxiao ^{[1
]}

Zhou, Xiaoyu ^{[1
]}

Ouyang, Zheng ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Precis Instrument, State Key Lab Precis Measurement Technol & Instrum, Beijing 100084, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2023年 / 95卷 / 29期

基金：

中国国家自然科学基金;

关键词：

PAPER SPRAY;

D O I：

10.1021/acs.analchem.3c01942

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In the past decade, mass spectrometry (MS) has been widelyusedfor a broad range of on-site applications. This is largely attributedto the rapid advancement of technologies, such as ambient ionizationand mass spectrometer miniaturization. Here, we report the developmentof the temperature-tuning desorption ionization (TTDI) method forversatile on-site applications using a miniature MS system. A uniquefeature of TTDI is its dynamic temperature range applicable from 30to 800 & DEG;C, which enables optimal desorption ionization appliedfor chemical and biological compounds through tuning the temperatureat the sampling spot. The versatility of TTDI has been demonstratedthrough on-site MS analysis of a variety of samples, such as explosiveson surfaces, drugs of abuse in biofluids, and screening biomarkersin tissues.

引用

页码：11099 / 11105

页数：7

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