RuPHOX-Ru catalyzed asymmetric Guerbet reaction of secondary alcohols with primary alcohols

被引：3
|
作者：
He, Jingli [1 ]
Li, Ruhui [1 ]
Kou, Xuezhen [1 ]
Fu, Daxu [2 ]
Liu, Delong [1 ]
Zhang, Wanbin [1 ,3 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
[2] Shanghai Inst Biomed & Pharmaceut Technol, 779 Laohumin Rd, Shanghai 200237, Peoples R China
[3] Shanghai Jiao Tong Univ, Frontier Sci Ctr Transformat Mol, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
来源：
TETRAHEDRON | 2023年 / 143卷
基金：
中国国家自然科学基金;
关键词：
RuPHOX-Ru; Asymmetric Guerbet reaction; Long-chain chiral alcohol; CHIRAL-GAMMA-LACTONES; TRANSFER HYDROGENATION; AMINO KETONES; IRIDIUM CATALYSTS; BETA-ALKYLATION; METHYL KETONES; METAL; LIGANDS; COMPLEXES; CYCLOALKANES;
D O I：
10.1016/j.tet.2023.133543
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient RuPHOX-Ru catalyzed asymmetric Guerbet reaction of secondary alcohols with a broad scope of primary alcohols has been developed, affording long-chain chiral alcohols in high yields with excellent enantioselectivities (up to 99% yield and 96% ee). In particular, alkyl primary alcohols could also react to give the desired products with good results. The protocol could be performed on a gram-scale, providing an alternative pathway with minimal environmental impact and high atom-economy for the preparation of chiral alcohol products. & COPY; 2023 Elsevier Ltd. All rights reserved.
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收藏
页数：9
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