Effect of liquid and solid test meals on symptoms and gastric myoelectrical activity in patients with gastroparesis and functional dyspepsia

被引:7
|
作者
Koch, Kenneth L. [1 ]
Van Natta, Mark [2 ]
Parkman, Henry P. [3 ]
Grover, Madhusudan [4 ]
Abell, Thomas L. [5 ]
McCallum, Richard W. [6 ]
Shaltout, Hossam A. [7 ]
Sarosiek, Irene [6 ]
Farrugia, Gianrico [4 ]
Shulman, Robert J. [8 ]
Tonascia, James [2 ]
Miriel, Laura [2 ]
Hamilton, Frank [9 ]
Pasricha, Pankaj J. [10 ]
机构
[1] Wake Forest Univ, Sect Gastroenterol, Winston Salem, NC 27157 USA
[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA
[3] Temple Univ, Sect Gastroenterol, Philadelphia, PA 19122 USA
[4] Mayo Clin, Mayo Clin Gastroenterol & Hepatol, Rochester, MN USA
[5] Univ Louisville, Digest & Liver Hlth, Louisville, KY 40292 USA
[6] Texas Tech Univ, Div Gastroenterol, El Paso, TX USA
[7] Wake Forest Univ, Cardiovasc Sci Ctr, Winston Salem, NC 27157 USA
[8] Baylor Coll Med, Childrens Nutr Res Ctr, Houston, TX 77030 USA
[9] NIDDK, Bethesda, MD 20892 USA
[10] Johns Hopkins Bayview Med Ctr, Ctr Neurogastroenterol, Baltimore, MD 21224 USA
来源
NEUROGASTROENTEROLOGY AND MOTILITY | 2023年 / 35卷 / 02期
关键词
functional dyspepsia; gastric dysrhythmias; gastroparesis; nutrient bar meal; postprandial distress syndrome; water load satiety test; CHRONIC UNEXPLAINED NAUSEA; WATER LOAD TEST; INTERSTITIAL-CELLS; ELECTROGASTROGRAM; CISAPRIDE; DISEASE; CAJAL;
D O I
10.1111/nmo.14376
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Patients with gastroparesis (GP) and functional dyspepsia (FD) have similar symptoms, but the pathophysiology of postprandial symptoms remains uncertain. Aims To compare symptoms and gastric myoelectrical activity (GMA) after liquid and solid test meals in patients with GP and FD. Methods Patients enrolled in the Gastroparesis Clinical Research Consortium Registry were studied. Clinical characteristics were measured with standard questionnaires. GP was determined by 4-h solid-phase gastric scintigraphy. GMA was measured using electrogastrography before and after ingestion of a water load or nutrient bar on separate days. Symptoms were measured on visual analog scales. GMA responses to the water load for individual patients were also determined. Results 284 patients with GP and 113 with FD were identified who ingested both test meals. Patients with GP and FD had similar maximal tolerated volumes of water [mean (SD) 378 (218) ml vs. 402 (226) ml, p = 0.23] and reported similar intensity of fullness, nausea, bloating, and abdominal discomfort after the test meals. Twenty-six percent and 19% of the patients with GP and FD, respectively, ingested subthreshold (<238 ml) volumes of water (p = 0.15). Gastric dysrhythmias were recorded in 66% of the GP and 65% of the FD patients after the water load. Symptoms and GMA were similar in both groups after ingestion of the nutrient bar. Conclusion The similarity in GMA responses and symptoms after ingestion of solid or liquid test meals suggests GP and FD are closely related gastric neuromuscular disorders.
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页数:13
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