Intracellular IL-23 Receptor (IL-23R) Is a Regulator of Mitotic Spindle and Centrosome Formation and Is Essential for AML Viability

被引:0
|
作者
Duong, Nathan [1 ]
Khan, Dilshad H. [2 ]
Thomas, Geethu Emily [1 ]
Hurren, Rose [1 ]
Lee, Jong Bok [3 ]
St-Germain, Jonathan [2 ]
Drimmer, Lily [1 ]
Yan, Yongran [2 ]
Maclean, Neil [1 ]
Gronda, Marcela [1 ]
Rondeau, Vincent [1 ]
Brown, Brandon D. [4 ]
Jones, Courtney L. [2 ]
Chang, Hong [5 ]
Arruda, Andrea [2 ]
Minden, Mark D. [2 ]
Zhang, Li [3 ]
Kornblau, Steven M. [6 ]
Raught, Brian [2 ]
Spadavecchio, Vito [7 ]
Schimmer, Aaron D. [1 ]
机构
[1] UHN, Princess Margaret Canc Ctr, Toronto, ON, Canada
[2] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada
[3] UHN, Toronto Gen Hosp, Toronto, ON, Canada
[4] Univ Texas MD Anderson Canc Ctr, Dept Pediat, Houston, TX 77030 USA
[5] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[6] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA
[7] Interlinked Therapeut LLC, Portland, OR USA
关键词
D O I
10.1182/blood-2023-174536
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页数:3
相关论文
共 50 条
  • [41] Increased IL-23 receptor, TNF-α and IL-6 expression in individuals with the IL23R-IL12R132 locus polymorphism
    Cavus, Filiz
    Ulusoy, Canan
    Orcen, Arda
    Gul, Ahmet
    Tuzun, Erdem
    Vural, Burcak
    IMMUNOLOGY LETTERS, 2014, 160 (01) : 96 - 98
  • [42] Association of IL-23r variants and ankylosing spondylitis (AS)
    Rahman, P.
    Inman, R. D.
    Gladman, D. D.
    Reeve, J.
    Wang, N.
    Peddle, L.
    Maksymowych, W. P.
    ANNALS OF THE RHEUMATIC DISEASES, 2007, 66 : 83 - 83
  • [43] Increased IL-23 receptor expression is observed on KIR3DL2+CD4+T cells in Ankylosing Spondylitis and correlates with IL-23R polymorphisms
    Ridley, A.
    Cohen, C.
    Karaderi, T.
    Kollnberger, S.
    Wong-Baeza, I.
    Shaw, J.
    Wordsworth, P.
    Bowness, P.
    IMMUNOLOGY, 2013, 140 : 140 - 141
  • [44] Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1
    Bloch, Yehudi
    Bouchareychas, Laura
    Merceron, Romain
    Skladanowska, Katarzyna
    Van den Bossche, Lien
    Detry, Sammy
    Govindarajan, Srinath
    Elewaut, Dirk
    Haerynck, Filomeen
    Dullaers, Melissa
    Adamopoulos, Iannis E.
    Savvides, Savvas N.
    IMMUNITY, 2018, 48 (01) : 45 - +
  • [45] IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants
    de Paus, Roelof A.
    van de Wetering, Diederik
    van Dissel, Jaap T.
    van de Vosse, Esther
    MOLECULAR IMMUNOLOGY, 2008, 45 (15) : 3889 - 3895
  • [46] Increased IL-23 Receptor Expression Is Observed On KIR3DL2+CD4+T Cells In Ankylosing Spondylitis and Correlates With IL-23R Polymorphisms
    Ridley, A.
    Cohen, C.
    Karaderi, T.
    Kollnberger, S.
    Wong-Baeza, I.
    Shaw, J.
    Wordsworth, P.
    Bowness, P.
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S302 - S303
  • [47] How widely is IL-23R implicated in inflammatory disease? IL23R gene polymorphisms and sarcoidosis
    Kim, Hyun Soo
    Doyle, Trudy
    Goodwin, Kelley
    Lim, Lyndell
    Allada, Gopal
    Smith, Justine
    Lewis, Jinnell
    Austin, Carrie
    Rosenbaum, James
    Martin, Tammy
    CLINICAL IMMUNOLOGY, 2008, 127 : S141 - S141
  • [48] IL-23 induced signaling and IL-23 receptor expression in human CD4 T cells
    Mat, Nor Fazila Che
    Guzzo, Christina
    Gee, Katrina
    CYTOKINE, 2009, 48 (1-2) : 108 - 108
  • [49] IL-23 Acts through IL-23R+Tfh cells to Promote Pathogenic IgG Autoantibody Formation in Lupus
    Hong, Huixian
    Wu, Qi
    Yang, PingAr
    Luo, Bao
    Li, Jun
    Li, Hao
    Cua, Daniel
    Hsu, Hui-Chen
    Mountz, John D.
    ARTHRITIS & RHEUMATOLOGY, 2018, 70
  • [50] The associations of T cell subsets, serumcytokines (IL-23, IL-17, TNF-α) and IL-23R and IL-12B gene polymorphisms with disease activity in patients with psoriasis
    Tarafder, Shirin
    Sultana, Sabia Shahin
    Nigar, Ismet
    Asaduzzaman, A. T. M.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2021, 41 (SUPPL 1) : S77 - S77